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Northcott Lab:
Paul A. Northcott Publications

 

Original articles (past five years):

Gottardo, N. G., Hansford, J. R., McGlade, J. P., Alvaro, F., Ashley, D. M., Bailey, S., Baker, D. L., Bourdeaut, F., Cho, Y. J., Clay, M., Clifford, S. C., Cohn, R. J., Cole, C. H., Dallas, P. B., Downie, P., Doz, F., Ellison, D. W., Endersby, R., Fisher, P. G., Hassall, T., Heath, J. A., Hii, H. L., Jones, D. T., Junckerstorff, R., Kellie, S., Kool, M., Kotecha, R. S., Lichter, P., Laughton, S. J., Lee, S., McCowage, G., Northcott, P. A., Olson, J. M., Packer, R. J., Pfister, S. M., Pietsch, T., Pizer, B., Pomeroy, S. L., Remke, M., Robinson, G. W., Rutkowski, S., Schoep, T., Shelat, A. A., Stewart, C. F., Sullivan, M., Taylor, M. D., Wainwright, B., Walwyn, T., Weiss, W. A., Williamson, D. & Gajjar, A. Medulloblastoma Down Under 2013: a report from the third annual meeting of the International Medulloblastoma Working Group. Acta Neuropathol 127, 189-201, doi:10.1007/s00401-013-1213-7 (2014).

Hovestadt, V., Jones, D. T., Picelli, S., Wang, W., Kool, M., Northcott, P. A., Sultan, M., Stachurski, K., Ryzhova, M., Warnatz, H. J., Ralser, M., Brun, S., Bunt, J., Jager, N., Kleinheinz, K., Erkek, S., Weber, U. D., Bartholomae, C. C., von Kalle, C., Lawerenz, C., Eils, J., Koster, J., Versteeg, R., Milde, T., Witt, O., Schmidt, S., Wolf, S., Pietsch, T., Rutkowski, S., Scheurlen, W., Taylor, M. D., Brors, B., Felsberg, J., Reifenberger, G., Borkhardt, A., Lehrach, H., Wechsler-Reya, R. J., Eils, R., Yaspo, M. L., Landgraf, P., Korshunov, A., Zapatka, M., Radlwimmer, B., Pfister, S. M. & Lichter, P. Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing. Nature 510, 537-541, doi:10.1038/nature13268 (2014).

Kool, M., Jones, D. T., Jager, N., Northcott, P. A., Pugh, T. J., Hovestadt, V., Piro, R. M., Esparza, L. A., Markant, S. L., Remke, M., Milde, T., Bourdeaut, F., Ryzhova, M., Sturm, D., Pfaff, E., Stark, S., Hutter, S., Seker-Cin, H., Johann, P., Bender, S., Schmidt, C., Rausch, T., Shih, D., Reimand, J., Sieber, L., Wittmann, A., Linke, L., Witt, H., Weber, U. D., Zapatka, M., Konig, R., Beroukhim, R., Bergthold, G., van Sluis, P., Volckmann, R., Koster, J., Versteeg, R., Schmidt, S., Wolf, S., Lawerenz, C., Bartholomae, C. C., von Kalle, C., Unterberg, A., Herold-Mende, C., Hofer, S., Kulozik, A. E., von Deimling, A., Scheurlen, W., Felsberg, J., Reifenberger, G., Hasselblatt, M., Crawford, J. R., Grant, G. A., Jabado, N., Perry, A., Cowdrey, C., Croul, S., Zadeh, G., Korbel, J. O., Doz, F., Delattre, O., Bader, G. D., McCabe, M. G., Collins, V. P., Kieran, M. W., Cho, Y. J., Pomeroy, S. L., Witt, O., Brors, B., Taylor, M. D., Schuller, U., Korshunov, A., Eils, R., Wechsler-Reya, R. J., Lichter, P., Pfister, S. M. & Project, I. P. T. Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition. Cancer Cell 25, 393-405, doi:10.1016/j.ccr.2014.02.004 (2014).

Korshunov, A., Sturm, D., Ryzhova, M., Hovestadt, V., Gessi, M., Jones, D. T., Remke, M., Northcott, P., Perry, A., Picard, D., Rosenblum, M., Antonelli, M., Aronica, E., Schuller, U., Hasselblatt, M., Woehrer, A., Zheludkova, O., Kumirova, E., Puget, S., Taylor, M. D., Giangaspero, F., Peter Collins, V., von Deimling, A., Lichter, P., Huang, A., Pietsch, T., Pfister, S. M. & Kool, M. Embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma, and medulloepithelioma share molecular similarity and comprise a single clinicopathological entity. Acta Neuropathol 128, 279-289, doi:10.1007/s00401-013-1228-0 (2014).

Mack, S. C., Witt, H., Piro, R. M., Gu, L., Zuyderduyn, S., Stutz, A. M., Wang, X., Gallo, M., Garzia, L., Zayne, K., Zhang, X., Ramaswamy, V., Jager, N., Jones, D. T., Sill, M., Pugh, T. J., Ryzhova, M., Wani, K. M., Shih, D. J., Head, R., Remke, M., Bailey, S. D., Zichner, T., Faria, C. C., Barszczyk, M., Stark, S., Seker-Cin, H., Hutter, S., Johann, P., Bender, S., Hovestadt, V., Tzaridis, T., Dubuc, A. M., Northcott, P. A., Peacock, J., Bertrand, K. C., Agnihotri, S., Cavalli, F. M., Clarke, I., Nethery-Brokx, K., Creasy, C. L., Verma, S. K., Koster, J., Wu, X., Yao, Y., Milde, T., Sin-Chan, P., Zuccaro, J., Lau, L., Pereira, S., Castelo-Branco, P., Hirst, M., Marra, M. A., Roberts, S. S., Fults, D., Massimi, L., Cho, Y. J., Van Meter, T., Grajkowska, W., Lach, B., Kulozik, A. E., von Deimling, A., Witt, O., Scherer, S. W., Fan, X., Muraszko, K. M., Kool, M., Pomeroy, S. L., Gupta, N., Phillips, J., Huang, A., Tabori, U., Hawkins, C., Malkin, D., Kongkham, P. N., Weiss, W. A., Jabado, N., Rutka, J. T., Bouffet, E., Korbel, J. O., Lupien, M., Aldape, K. D., Bader, G. D., Eils, R., Lichter, P., Dirks, P. B., Pfister, S. M., Korshunov, A. & Taylor, M. D. Epigenomic alterations define lethal CIMP-positive ependymomas of infancy. Nature 506, 445-450, doi:10.1038/nature13108 (2014).

Mille, F., Tamayo-Orrego, L., Levesque, M., Remke, M., Korshunov, A., Cardin, J., Bouchard, N., Izzi, L., Kool, M., Northcott, P. A., Taylor, M. D., Pfister, S. M. & Charron, F. The Shh receptor Boc promotes progression of early medulloblastoma to advanced tumors. Dev Cell 31, 34-47, doi:10.1016/j.devcel.2014.08.010 (2014).

Northcott, P. A., Lee, C., Zichner, T., Stutz, A. M., Erkek, S., Kawauchi, D., Shih, D. J., Hovestadt, V., Zapatka, M., Sturm, D., Jones, D. T., Kool, M., Remke, M., Cavalli, F. M., Zuyderduyn, S., Bader, G. D., VandenBerg, S., Esparza, L. A., Ryzhova, M., Wang, W., Wittmann, A., Stark, S., Sieber, L., Seker-Cin, H., Linke, L., Kratochwil, F., Jager, N., Buchhalter, I., Imbusch, C. D., Zipprich, G., Raeder, B., Schmidt, S., Diessl, N., Wolf, S., Wiemann, S., Brors, B., Lawerenz, C., Eils, J., Warnatz, H. J., Risch, T., Yaspo, M. L., Weber, U. D., Bartholomae, C. C., von Kalle, C., Turanyi, E., Hauser, P., Sanden, E., Darabi, A., Siesjo, P., Sterba, J., Zitterbart, K., Sumerauer, D., van Sluis, P., Versteeg, R., Volckmann, R., Koster, J., Schuhmann, M. U., Ebinger, M., Grimes, H. L., Robinson, G. W., Gajjar, A., Mynarek, M., von Hoff, K., Rutkowski, S., Pietsch, T., Scheurlen, W., Felsberg, J., Reifenberger, G., Kulozik, A. E., von Deimling, A., Witt, O., Eils, R., Gilbertson, R. J., Korshunov, A., Taylor, M. D., Lichter, P., Korbel, J. O., Wechsler-Reya, R. J. & Pfister, S. M. Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma. Nature 511, 428-434, doi:10.1038/nature13379 (2014).

Pietsch, T., Schmidt, R., Remke, M., Korshunov, A., Hovestadt, V., Jones, D. T., Felsberg, J., Kaulich, K., Goschzik, T., Kool, M., Northcott, P. A., von Hoff, K., von Bueren, A. O., Friedrich, C., Mynarek, M., Skladny, H., Fleischhack, G., Taylor, M. D., Cremer, F., Lichter, P., Faldum, A., Reifenberger, G., Rutkowski, S. & Pfister, S. M. Prognostic significance of clinical, histopathological, and molecular characteristics of medulloblastomas in the prospective HIT2000 multicenter clinical trial cohort. Acta Neuropathol 128, 137-149, doi:10.1007/s00401-014-1276-0 (2014).

Poschl, J., Stark, S., Neumann, P., Grobner, S., Kawauchi, D., Jones, D. T., Northcott, P. A., Lichter, P., Pfister, S. M., Kool, M. & Schuller, U. Genomic and transcriptomic analyses match medulloblastoma mouse models to their human counterparts. Acta Neuropathol 128, 123-136, doi:10.1007/s00401-014-1297-8 (2014).

Ramaswamy, V., Remke, M., Shih, D., Wang, X., Northcott, P. A., Faria, C. C., Raybaud, C., Tabori, U., Hawkins, C., Rutka, J., Taylor, M. D. & Bouffet, E. Duration of the pre-diagnostic interval in medulloblastoma is subgroup dependent. Pediatr Blood Cancer 61, 1190-1194, doi:10.1002/pbc.25002 (2014).

Shih, D. J., Northcott, P. A., Remke, M., Korshunov, A., Ramaswamy, V., Kool, M., Luu, B., Yao, Y., Wang, X., Dubuc, A. M., Garzia, L., Peacock, J., Mack, S. C., Wu, X., Rolider, A., Morrissy, A. S., Cavalli, F. M., Jones, D. T., Zitterbart, K., Faria, C. C., Schuller, U., Kren, L., Kumabe, T., Tominaga, T., Shin Ra, Y., Garami, M., Hauser, P., Chan, J. A., Robinson, S., Bognar, L., Klekner, A., Saad, A. G., Liau, L. M., Albrecht, S., Fontebasso, A., Cinalli, G., De Antonellis, P., Zollo, M., Cooper, M. K., Thompson, R. C., Bailey, S., Lindsey, J. C., Di Rocco, C., Massimi, L., Michiels, E. M., Scherer, S. W., Phillips, J. J., Gupta, N., Fan, X., Muraszko, K. M., Vibhakar, R., Eberhart, C. G., Fouladi, M., Lach, B., Jung, S., Wechsler-Reya, R. J., Fevre-Montange, M., Jouvet, A., Jabado, N., Pollack, I. F., Weiss, W. A., Lee, J. Y., Cho, B. K., Kim, S. K., Wang, K. C., Leonard, J. R., Rubin, J. B., de Torres, C., Lavarino, C., Mora, J., Cho, Y. J., Tabori, U., Olson, J. M., Gajjar, A., Packer, R. J., Rutkowski, S., Pomeroy, S. L., French, P. J., Kloosterhof, N. K., Kros, J. M., Van Meir, E. G., Clifford, S. C., Bourdeaut, F., Delattre, O., Doz, F. F., Hawkins, C. E., Malkin, D., Grajkowska, W. A., Perek-Polnik, M., Bouffet, E., Rutka, J. T., Pfister, S. M. & Taylor, M. D. Cytogenetic prognostication within medulloblastoma subgroups. J Clin Oncol 32, 886-896, doi:10.1200/JCO.2013.50.9539 (2014).

Vanner, R. J., Remke, M., Gallo, M., Selvadurai, H. J., Coutinho, F., Lee, L., Kushida, M., Head, R., Morrissy, S., Zhu, X., Aviv, T., Voisin, V., Clarke, I. D., Li, Y., Mungall, A. J., Moore, R. A., Ma, Y., Jones, S. J., Marra, M. A., Malkin, D., Northcott, P. A., Kool, M., Pfister, S. M., Bader, G., Hochedlinger, K., Korshunov, A., Taylor, M. D. & Dirks, P. B. Quiescent sox2(+) cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma. Cancer Cell 26, 33-47, doi:10.1016/j.ccr.2014.05.005 (2014).

Zhukova, N., Ramaswamy, V., Remke, M., Martin, D. C., Castelo-Branco, P., Zhang, C. H., Fraser, M., Tse, K., Poon, R., Shih, D. J., Baskin, B., Ray, P. N., Bouffet, E., Dirks, P., von Bueren, A. O., Pfaff, E., Korshunov, A., Jones, D. T., Northcott, P. A., Kool, M., Pugh, T. J., Pomeroy, S. L., Cho, Y. J., Pietsch, T., Gessi, M., Rutkowski, S., Bognar, L., Cho, B. K., Eberhart, C. G., Conter, C. F., Fouladi, M., French, P. J., Grajkowska, W. A., Gupta, N., Hauser, P., Jabado, N., Vasiljevic, A., Jung, S., Kim, S. K., Klekner, A., Kumabe, T., Lach, B., Leonard, J. R., Liau, L. M., Massimi, L., Pollack, I. F., Ra, Y. S., Rubin, J. B., Van Meir, E. G., Wang, K. C., Weiss, W. A., Zitterbart, K., Bristow, R. G., Alman, B., Hawkins, C. E., Malkin, D., Clifford, S. C., Pfister, S. M., Taylor, M. D. & Tabori, U. WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma. Acta Neuropathol Commun 2, 174, doi:10.1186/s40478-014-0174-y (2014).

Buss, M. C., Remke, M., Lee, J., Gandhi, K., Schniederjan, M. J., Kool, M., Northcott, P. A., Pfister, S. M., Taylor, M. D. & Castellino, R. C. The WIP1 oncogene promotes progression and invasion of aggressive medulloblastoma variants. Oncogene 34, 1126-1140, doi:10.1038/onc.2014.37 (2015).

Faria, C. C., Golbourn, B. J., Dubuc, A. M., Remke, M., Diaz, R. J., Agnihotri, S., Luck, A., Sabha, N., Olsen, S., Wu, X., Garzia, L., Ramaswamy, V., Mack, S. C., Wang, X., Leadley, M., Reynaud, D., Ermini, L., Post, M., Northcott, P. A., Pfister, S. M., Croul, S. E., Kool, M., Korshunov, A., Smith, C. A., Taylor, M. D. & Rutka, J. T. Foretinib is effective therapy for metastatic sonic hedgehog medulloblastoma. Cancer Res 75, 134-146, doi:10.1158/0008-5472.CAN-13-3629 (2015).

Korshunov, A., Ryzhova, M., Hovestadt, V., Bender, S., Sturm, D., Capper, D., Meyer, J., Schrimpf, D., Kool, M., Northcott, P. A., Zheludkova, O., Milde, T., Witt, O., Kulozik, A. E., Reifenberger, G., Jabado, N., Perry, A., Lichter, P., von Deimling, A., Pfister, S. M. & Jones, D. T. Integrated analysis of pediatric glioblastoma reveals a subset of biologically favorable tumors with associated molecular prognostic markers. Acta Neuropathol 129, 669-678, doi:10.1007/s00401-015-1405-4 (2015).
Mardin, B. R., Drainas, A. P., Waszak, S. M., Weischenfeldt, J., Isokane, M., Stutz, A. M., Raeder, B., Efthymiopoulos, T., Buccitelli, C., Segura-Wang, M., Northcott, P., Pfister, S. M., Lichter, P., Ellenberg, J. & Korbel, J. O. A cell-based model system links chromothripsis with hyperploidy. Mol Syst Biol 11, 828, doi:10.15252/msb.20156505 (2015).

Sanden, E., Dyberg, C., Krona, C., Visse, E., Caren, H., Northcott, P. A., Kool, M., Stahl, N., Persson, A., Englund, E., Johnsen, J. I., Siesjo, P. & Darabi, A. Aberrant immunostaining pattern of the CD24 glycoprotein in clinical samples and experimental models of pediatric medulloblastomas. J Neurooncol 123, 1-13, doi:10.1007/s11060-015-1758-5 (2015).

Snuderl, M., Triscott, J., Northcott, P. A., Shih, H. A., Kong, E., Robinson, H., Dunn, S. E., Iafrate, A. J. & Yip, S. Deep sequencing identifies IDH1 R132S mutation in adult medulloblastoma. J Clin Oncol 33, e27-31, doi:10.1200/JCO.2013.49.4864 (2015).

Staal, J. A., Lau, L. S., Zhang, H., Ingram, W. J., Hallahan, A. R., Northcott, P. A., Pfister, S. M., Wechsler-Reya, R. J., Rusert, J. M., Taylor, M. D., Cho, Y. J., Packer, R. J., Brown, K. J. & Rood, B. R. Proteomic profiling of high risk medulloblastoma reveals functional biology. Oncotarget 6, 14584-14595, doi:10.18632/oncotarget.3927 (2015).

Wang, X., Dubuc, A. M., Ramaswamy, V., Mack, S., Gendoo, D. M., Remke, M., Wu, X., Garzia, L., Luu, B., Cavalli, F., Peacock, J., Lopez, B., Skowron, P., Zagzag, D., Lyden, D., Hoffman, C., Cho, Y. J., Eberhart, C., MacDonald, T., Li, X. N., Van Meter, T., Northcott, P. A., Haibe-Kains, B., Hawkins, C., Rutka, J. T., Bouffet, E., Pfister, S. M., Korshunov, A. & Taylor, M. D. Medulloblastoma subgroups remain stable across primary and metastatic compartments. Acta Neuropathol 129, 449-457, doi:10.1007/s00401-015-1389-0 (2015).

Zuckermann, M., Hovestadt, V., Knobbe-Thomsen, C. B., Zapatka, M., Northcott, P. A., Schramm, K., Belic, J., Jones, D. T., Tschida, B., Moriarity, B., Largaespada, D., Roussel, M. F., Korshunov, A., Reifenberger, G., Pfister, S. M., Lichter, P., Kawauchi, D. & Gronych, J. Somatic CRISPR/Cas9-mediated tumour suppressor disruption enables versatile brain tumour modelling. Nat Commun 6, 7391, doi:10.1038/ncomms8391 (2015).

Bassett, E. A., Tokarew, N., Allemano, E. A., Mazerolle, C., Morin, K., Mears, A. J., McNeill, B., Ringuette, R., Campbell, C., Smiley, S., Pokrajac, N. T., Dubuc, A. M., Ramaswamy, V., Northcott, P. A., Remke, M., Monnier, P. P., Potter, D., Paes, K., Kirkpatrick, L. L., Coker, K. J., Rice, D. S., Perez-Iratxeta, C., Taylor, M. D. & Wallace, V. A. Norrin/Frizzled4 signalling in the preneoplastic niche blocks medulloblastoma initiation. Elife 5, doi:10.7554/eLife.16764 (2016).

Broniscer, A., Chamdine, O., Hwang, S., Lin, T., Pounds, S., Onar-Thomas, A., Shurtleff, S., Allen, S., Gajjar, A., Northcott, P. & Orr, B. A. Gliomatosis cerebri in children shares molecular characteristics with other pediatric gliomas. Acta Neuropathol 131, 299-307, doi:10.1007/s00401-015-1532-y (2016).

Johann, P. D., Erkek, S., Zapatka, M., Kerl, K., Buchhalter, I., Hovestadt, V., Jones, D. T. W., Sturm, D., Hermann, C., Segura Wang, M., Korshunov, A., Rhyzova, M., Grobner, S., Brabetz, S., Chavez, L., Bens, S., Groschel, S., Kratochwil, F., Wittmann, A., Sieber, L., Georg, C., Wolf, S., Beck, K., Oyen, F., Capper, D., van Sluis, P., Volckmann, R., Koster, J., Versteeg, R., von Deimling, A., Milde, T., Witt, O., Kulozik, A. E., Ebinger, M., Shalaby, T., Grotzer, M., Sumerauer, D., Zamecnik, J., Mora, J., Jabado, N., Taylor, M. D., Huang, A., Aronica, E., Bertoni, A., Radlwimmer, B., Pietsch, T., Schuller, U., Schneppenheim, R., Northcott, P. A., Korbel, J. O., Siebert, R., Fruhwald, M. C., Lichter, P., Eils, R., Gajjar, A., Hasselblatt, M., Pfister, S. M. & Kool, M. Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes. Cancer Cell 29, 379-393, doi:10.1016/j.ccell.2016.02.001 (2016).

Lin, C. Y., Erkek, S., Tong, Y., Yin, L., Federation, A. J., Zapatka, M., Haldipur, P., Kawauchi, D., Risch, T., Warnatz, H. J., Worst, B. C., Ju, B., Orr, B. A., Zeid, R., Polaski, D. R., Segura-Wang, M., Waszak, S. M., Jones, D. T., Kool, M., Hovestadt, V., Buchhalter, I., Sieber, L., Johann, P., Chavez, L., Groschel, S., Ryzhova, M., Korshunov, A., Chen, W., Chizhikov, V. V., Millen, K. J., Amstislavskiy, V., Lehrach, H., Yaspo, M. L., Eils, R., Lichter, P., Korbel, J. O., Pfister, S. M., Bradner, J. E. & Northcott, P. A. Active medulloblastoma enhancers reveal subgroup-specific cellular origins. Nature 530, 57-62, doi:10.1038/nature16546 (2016).

Morrissy, A. S., Garzia, L., Shih, D. J., Zuyderduyn, S., Huang, X., Skowron, P., Remke, M., Cavalli, F. M., Ramaswamy, V., Lindsay, P. E., Jelveh, S., Donovan, L. K., Wang, X., Luu, B., Zayne, K., Li, Y., Mayoh, C., Thiessen, N., Mercier, E., Mungall, K. L., Ma, Y., Tse, K., Zeng, T., Shumansky, K., Roth, A. J., Shah, S., Farooq, H., Kijima, N., Holgado, B. L., Lee, J. J., Matan-Lithwick, S., Liu, J., Mack, S. C., Manno, A., Michealraj, K. A., Nor, C., Peacock, J., Qin, L., Reimand, J., Rolider, A., Thompson, Y. Y., Wu, X., Pugh, T., Ally, A., Bilenky, M., Butterfield, Y. S., Carlsen, R., Cheng, Y., Chuah, E., Corbett, R. D., Dhalla, N., He, A., Lee, D., Li, H. I., Long, W., Mayo, M., Plettner, P., Qian, J. Q., Schein, J. E., Tam, A., Wong, T., Birol, I., Zhao, Y., Faria, C. C., Pimentel, J., Nunes, S., Shalaby, T., Grotzer, M., Pollack, I. F., Hamilton, R. L., Li, X. N., Bendel, A. E., Fults, D. W., Walter, A. W., Kumabe, T., Tominaga, T., Collins, V. P., Cho, Y. J., Hoffman, C., Lyden, D., Wisoff, J. H., Garvin, J. H., Jr., Stearns, D. S., Massimi, L., Schuller, U., Sterba, J., Zitterbart, K., Puget, S., Ayrault, O., Dunn, S. E., Tirapelli, D. P., Carlotti, C. G., Wheeler, H., Hallahan, A. R., Ingram, W., MacDonald, T. J., Olson, J. J., Van Meir, E. G., Lee, J. Y., Wang, K. C., Kim, S. K., Cho, B. K., Pietsch, T., Fleischhack, G., Tippelt, S., Ra, Y. S., Bailey, S., Lindsey, J. C., Clifford, S. C., Eberhart, C. G., Cooper, M. K., Packer, R. J., Massimino, M., Garre, M. L., Bartels, U., Tabori, U., Hawkins, C. E., Dirks, P., Bouffet, E., Rutka, J. T., Wechsler-Reya, R. J., Weiss, W. A., Collier, L. S., Dupuy, A. J., Korshunov, A., Jones, D. T., Kool, M., Northcott, P. A., Pfister, S. M., Largaespada, D. A., Mungall, A. J., Moore, R. A., Jabado, N., Bader, G. D., Jones, S. J., Malkin, D., Marra, M. A. & Taylor, M. D. Divergent clonal selection dominates medulloblastoma at recurrence. Nature 529, 351-357, doi:10.1038/nature16478 (2016).

Oh, S., Flynn, R. A., Floor, S. N., Purzner, J., Martin, L., Do, B. T., Schubert, S., Vaka, D., Morrissy, S., Li, Y., Kool, M., Hovestadt, V., Jones, D. T., Northcott, P. A., Risch, T., Warnatz, H. J., Yaspo, M. L., Adams, C. M., Leib, R. D., Breese, M., Marra, M. A., Malkin, D., Lichter, P., Doudna, J. A., Pfister, S. M., Taylor, M. D., Chang, H. Y. & Cho, Y. J. Medulloblastoma-associated DDX3 variant selectively alters the translational response to stress. Oncotarget 7, 28169-28182, doi:10.18632/oncotarget.8612 (2016).

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Mack, S. C., Pajtler, K. W., Chavez, L., Okonechnikov, K., Bertrand, K. C., Wang, X., Erkek, S., Federation, A., Song, A., Lee, C., Wang, X., McDonald, L., Morrow, J. J., Saiakhova, A., Sin-Chan, P., Wu, Q., Michaelraj, K. A., Miller, T. E., Hubert, C. G., Ryzhova, M., Garzia, L., Donovan, L., Dombrowski, S., Factor, D. C., Luu, B., Valentim, C. L. L., Gimple, R. C., Morton, A., Kim, L., Prager, B. C., Lee, J. J. Y., Wu, X., Zuccaro, J., Thompson, Y., Holgado, B. L., Reimand, J., Ke, S. Q., Tropper, A., Lai, S., Vijayarajah, S., Doan, S., Mahadev, V., Minan, A. F., Grobner, S. N., Lienhard, M., Zapatka, M., Huang, Z., Aldape, K. D., Carcaboso, A. M., Houghton, P. J., Keir, S. T., Milde, T., Witt, H., Li, Y., Li, C. J., Bian, X. W., Jones, D. T. W., Scott, I., Singh, S. K., Huang, A., Dirks, P. B., Bouffet, E., Bradner, J. E., Ramaswamy, V., Jabado, N., Rutka, J. T., Northcott, P. A., Lupien, M., Lichter, P., Korshunov, A., Scacheri, P. C., Pfister, S. M., Kool, M., Taylor, M. D. & Rich, J. N. Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling. Nature 553, 101-105, doi:10.1038/nature25169 (2018).

Waszak, S. M., Northcott, P. A., Buchhalter, I., Robinson, G. W., Sutter, C., Groebner, S., Grund, K. B., Brugieres, L., Jones, D. T. W., Pajtler, K. W., Morrissy, A. S., Kool, M., Sturm, D., Chavez, L., Ernst, A., Brabetz, S., Hain, M., Zichner, T., Segura-Wang, M., Weischenfeldt, J., Rausch, T., Mardin, B. R., Zhou, X., Baciu, C., Lawerenz, C., Chan, J. A., Varlet, P., Guerrini-Rousseau, L., Fults, D. W., Grajkowska, W., Hauser, P., Jabado, N., Ra, Y. S., Zitterbart, K., Shringarpure, S. S., De La Vega, F. M., Bustamante, C. D., Ng, H. K., Perry, A., MacDonald, T. J., Hernaiz Driever, P., Bendel, A. E., Bowers, D. C., McCowage, G., Chintagumpala, M. M., Cohn, R., Hassall, T., Fleischhack, G., Eggen, T., Wesenberg, F., Feychting, M., Lannering, B., Schuz, J., Johansen, C., Andersen, T. V., Roosli, M., Kuehni, C. E., Grotzer, M., Kjaerheim, K., Monoranu, C. M., Archer, T. C., Duke, E., Pomeroy, S. L., Shelagh, R., Frank, S., Sumerauer, D., Scheurlen, W., Ryzhova, M. V., Milde, T., Kratz, C. P., Samuel, D., Zhang, J., Solomon, D. A., Marra, M., Eils, R., Bartram, C. R., von Hoff, K., Rutkowski, S., Ramaswamy, V., Gilbertson, R. J., Korshunov, A., Taylor, M. D., Lichter, P., Malkin, D., Gajjar, A., Korbel, J. O. & Pfister, S. M. Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort. Lancet Oncol, 19, 785-798, doi:10.1016/S1470-2045(18)30242-0 (2018).

Robinson, G. W., Rudneva, V. A., Buchhalter, I., Billups, C. A., Waszak, S. W., Smith, K. S., Bowers, D. C., Bendel, A., Fisher, P. G., Partap, S., Crawford, J. R., Hassall, T., Indelicato, D. J., Boop, F., Klimo, P., Sabin, N. D., Patay, Z., Merchant, T. E., Stewart, C. F., Orr, B. A., Korbel, J. O., Jones, D. T. W., Sharma, T., Lichter, P., Kool, M., Korshunov, A., Pfister, S. M., Gilbertson, R. J., Sanders, R. P., Onar-Thomas, A., Ellison, D. W., Gajjar, A. & Northcott, P., A.Risk-adapted therapy for young children with medulloblastoma (SJYC07): therapeutic and molecular outcomes from a multicentre, phase 2 trial. Lancet Oncol, 19, 768-784, doi:10.1016/S1470-2045(18)30204-3 (2018).

Dhar, S. S., Zhao, D., Lin, T., Gu, B., Pal, K., Wu, S. J., Alam, H., Lv, J., Yun, K., Gopalakrishnan, V., Flores, E. R., Northcott, P. A., Rajaram, V., Li, W., Shilatifard, A., Sillitoe, R. V., Chen, K. & Lee, M. G. MLL4 Is Required to Maintain Broad H3K4me3 Peaks and Super-Enhancers at Tumor Suppressor Genes. Mol Cell, 70, 825-841 e826, doi:10.1016/j.molcel.2018.04.028 (2018).

Rivero-Hinojosa, S., Lau, L. S., Stampar, M., Staal, J., Zhang, H., Gordish-Dressman, H., Northcott, P. A., Pfister, S. M., Taylor, M. D., Brown, K. J. & Rood, B. R. Proteomic analysis of Medulloblastoma reveals functional biology with translational potential. Acta Neuropathol Commun, 6, 48, doi:10.1186/s40478-018-0548-7 (2018).

Archer, T. C., Ehrenberger, T., Mundt, F., Gold, M. P., Krug, K., Mah, C. K., Mahoney, E. L., Daniel, C. J., LeNail, A., Ramamoorthy, D., Mertins, P., Mani, D. R., Zhang, H., Gillette, M. A., Clauser, K., Noble, M., Tang, L. C., Pierre-Francois, J., Silterra, J., Jensen, J., Tamayo, P., Korshunov, A., Pfister, S. M., Kool, M., Northcott, P. A., Sears, R. C., Lipton, J. O., Carr, S. A., Mesirov, J. P., Pomeroy, S. L. & Fraenkel, E. Proteomics, Post-translational Modifications, and Integrative Analyses Reveal Molecular Heterogeneity within Medulloblastoma Subgroups. Cancer Cell, 34, 396-410 e398, doi:10.1016/j.ccell.2018.08.004 (2018).

Carter, R. A., Bihannic, L., Rosencrance, C., Hadley, J. L., Tong, Y., Phoenix, T. N., Natarajan, S., Easton, J., Northcott, P. A. & Gawad, C. A Single-Cell Transcriptional Atlas of the Developing Murine Cerebellum. Curr Biol, 28, 2910-2920 e2912, doi:10.1016/j.cub.2018.07.062 (2018).

 

Reviews (past five years):

Batora, N. V., Sturm, D., Jones, D. T., Kool, M., Pfister, S. M. & Northcott, P. A. Transitioning from genotypes to epigenotypes: why the time has come for medulloblastoma epigenomics. Neuroscience 264, 171-185, doi:10.1016/j.neuroscience.2013.07.030 (2014).

Northcott, P. A., Pfister, S. M. & Jones, D. T. Next-generation (epi)genetic drivers of childhood brain tumours and the outlook for targeted therapies. Lancet Oncol 16, e293-302, doi:10.1016/S1470-2045(14)71206-9 (2015).

Ramaswamy, V., Remke, M., Bouffet, E., Bailey, S., Clifford, S. C., Doz, F., Kool, M., Dufour, C., Vassal, G., Milde, T., Witt, O., von Hoff, K., Pietsch, T., Northcott, P. A., Gajjar, A., Robinson, G. W., Padovani, L., Andre, N., Massimino, M., Pizer, B., Packer, R., Rutkowski, S., Pfister, S. M., Taylor, M. D. & Pomeroy, S. L. Risk stratification of childhood medulloblastoma in the molecular era: the current consensus. Acta Neuropathol 131, 821-831, doi:10.1007/s00401-016-1569-6 (2016).

Mack, S. C. & Northcott, P. A. Genomic Analysis of Childhood Brain Tumors: Methods for Genome-Wide Discovery and Precision Medicine Become Mainstream. J Clin Oncol 35, 2346-2354, doi:10.1200/JCO.2017.72.9921 (2017).

Kumar, R., Liu, A. P. Y., Orr, B. A., Northcott, P. A. & Robinson, G. W. Advances in the classification of pediatric brain tumors through DNA methylation profiling: from research tool to frontline diagnostic. Cancer, doi:10.1002/cncr.31583 (2018).