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Mullighan Lab: People

PI
Charles G. Mullighan, MBBS(Hons), MSc, MD

Charles G. Mullighan, MBBS(Hons), MSc, MD
Member

Staff
Kathryn Roberts, PhD

Kathryn Roberts, PhD
Scientific Manager

  • Subtype focus: Ph-like B-ALL, B-other ALL
  • Research interests: Defining the genomic landscape of acute leukemia to identify new subtypes and therapeutic targets.
  • Specialties: Patient sample coordinator, cell line culture, kinase signaling, patient-derived xenograft mouse models, pre-clinical studies
  • Hometown: Newcastle, New South Wales Australia
  • Email: kathryn.roberts@stjude.org
Ilaria Iacobucci, PhD

Ilaria Iacobucci, PhD
Staff Scientist

  • Subtype focus: Ph+ ALL; Ph-like ALL/EPOR-R; AML/AEL/MDS
  • Research interests: Understanding the genomic alterations underlying the pathogenesis of high risk myeloid and lymphoid leukemia subtypes in both children and adults.
  • Specialties: Genomic high-throughput analysis of primary samples, cloning, primary cell culture, functional assays, engineered and patient-derived xenograft mouse models, CRISPR/Cas9 engineering of murine hematopoietic stem cells and human cell lines, pre-clinical studies, mentor of several students.
  • Hometown: Bologna, Italy
  • Email: ilaria.iacobucci@stjude.org
Chunxu Qu, PhD

Chunxu Qu, PhD
Senior Bioinformatics Research Scientist

  • Research interests: Bioinformatics analysis
  • Specialties: Array and high throughput sequence analysis
  • Hometown: Shandong, China
  • Email: chunxu.qu@stjude.org
Yunchao Chang

Yunchao Chang, PhD
Research Lab Specialist

  • Subtype focus: B-ALL
  • Research interests: modelling CREBBP mutations in human ALL cells and engineered mice, investigating the underlying mechanisms and identifying potential new therapies.
  • Specialties: Molecular cloning, epigenetics, ChIP, qPCR, primary cell culture, functional assay, mouse management.
  • Hometown: Shanxi, China
  • Email: yunchao.chang@stjude.org
Yaqi Zhao

Yaqi Zhao
Senior Research Technologist

  • Research interests: Genomic determinants of response to cancer immunotherapy
  • Specialties: Patient sample processing and organization, NGS submissions
  • Hometown: Qingdao, Shandong, China
  • Email: yaqi.zhao@stjude.org
Ashley Hill

Ashley Hill
Senior Research Technologist

  • Specialties: Patient sample processing and organization, NGS submissions, patient-derived xenograft mouse models
  • Hometown: Memphis, Tennessee USA
  • Email: ashley.hill@stjude.org
Pankaj Ghate

Pankaj Ghate, PhD
Senior Research Technologist
Subtype focus: Hypodiploid ALL

  • Research interests: Developing in vitro and in vivo models to study molecular mechanisms underlying hypodiploid ALL.
  • Specialties: Human Induced Pluripotent stem cells (hiPSCs), directed differentiation, high throughput cellular & molecular techniques, mammalian cell culture, engineered mouse models
  • Hometown: Pune, Maharashtra, India
  • Email: pankaj.ghate@stjude.org
Trainees
Lindsey Montefiori

Lindsey Montefiori, PhD
Post-doctoral Research Associate

  • Subtype focus: Mixed phenotype acute leukemia, WT1 alterations
  • Research interests: Understanding the molecular basis for gene dysregulation in pediatric leukemia
  • Specialties: High-throughput genomics assays to study gene regulation, 3D genome organization, epigenetics, leukemia modeling using iPSC-derived hematopoietic cells
  • Hometown: Nashville, Tennessee, USA
  • Email: lindsey.montefiori@stjude.org
Shunsuke Kimura

Shunsuke Kimura, PhD
Post-doctoral Research Associate

  • Subtype focus: T-ALL, NK/T-cell lymphoma
  • Research interests: Investigating genomic alterations underlying the pathogenesis of high risk pediatric leukemia
  • Specialties: Bioinformatics (whole exome sequencing, whole transcriptome sequencing, methylation array data analysis)
  • Hometown: Hiroshima, Japan
  • Email: shunsuke.kimura@stjude.org
Zhaohui Gu, PhD

Zhaohui Gu, PhD
Postdoctoral Research Associate

  • Subtype specialty: MEF2D fusions
  • Bioinformatics: WGS/WES/RNAseq and SNP/methylation array data analysis
  • Research interests: ALL subtyping based on gene expression profile and genetic alterations
  • Specialties: Bioinformatics
  • Hometown: Xi’an, Shaanxi, China
  • Email: zhaohui.gu@stjude.org
Kirsten Dickerson

Kirsten Dickerson
PhD Student, UTHSC

  • Subtype focus: ZNF384 Rearrangements in acute leukemia
  • Research interest: Transcription and epigenetic dysregulation in leukemia
  • Specialties: Cell culture, mouse engineering using CRISPR/Cas9, mouse colony management, epigenetic assays (ChIP-seq, ATAC-seq)
  • Hometown: Dyersburg, Tennessee, USA
  • Email: kirsten.dickerson@stjude.org