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Department of Biostatistics


Xiong, Tan, and Boyett (2003) introduce SCPRT methods for sequential designs of clinical trials for which the sequential test statistic can be approximated by Brownian motion on information time [0,1]. Xiong, Tan, and Boyett (2006) introduce SCPRT methods for monitoring clinical trials against historical controls.


Xiong (1995) introduces the general principle and methods of SCPRT and the detailed method for binary data. Tan and Xiong (1996) compare the SCPRT method with other sequential methods for clinical trials with binary data.

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