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Supplementary Information

Radial glia cells are candidate stem cells of ependymoma.

Michael D. Taylor, Christine Fuller, Xiaoping Su, Yongxing Liu, Patricia Jensen, Susan Magdaleno, James Dalton, Christopher Calabrese, Julian Board, Tobey MacDonald, Jim Rutka, Abhijit Guha, Amar Gajjar, Tom Curran, and Richard J. Gilbertson*

Cancer Cell 2005 Oct;8(4):323-35.

Summary

Tumors of the same histologic type often comprise clinically and molecularly distinct subgroups; however, the etiology of these subgroups is unknown. Here, we report that histologically identical, but genetically distinct, ependymomas exhibit patterns of gene expression that recapitulate those of radial glia cells in the corresponding region of the central nervous system. Cancer stem cells isolated from ependymomas displayed a radial glia phenotype and formed tumors when orthotopically transplanted in mice. These findings identify restricted populations of radial glia cells as candidate stem cells of the different subgroups of ependymoma, and they support a general hypothesis that subgroups of the same histologic tumor type are generated by different populations of progenitor cells in the tissues of origin.

Data Files

aCGH (32 gpr files)
aCGH.zip

27.6MB FTP HTTP
Affy. expression (29 files)
group1.zip (7 files)
- XXrjg165-epd-v5-u133a.CEL
- XXrjg172-epd-v5-u133a.CEL
- XXrjg174-epd-v5-u133a.CEL
- XXrjg230-epd-v5-u133a.CEL
- XXrjg232-epd-v5-u133a.CEL
- XXrjg236-epd-v5-u133a.CEL
- XXrjg241-epd-v5-u133a.CEL
21.4MB FTP HTTP
group2.zip (7 files)
- XXrjg249-epy-u133a.CEL
- XYrjg170-epd-v5-u133a.CEL
- XYrjg175-epd-v5-u133a.CEL
- XYrjg176-epd-v5-u133a.CEL
- XYrjg177-epd-v5-u133a.CEL
- XYrjg178-epd-v5-u133a.CEL
- XYrjg179-epd-v5-u133a.CEL
21.2MB FTP HTTP
group3.zip (8 files)
- XYrjg181-epd-v5-u133a.CEL
- XYrjg182-epd-v5-u133a.CEL
- XYrjg227-epd-v5-u133a.CEL
- XYrjg231-epd-v5-u133a.CEL
- XYrjg233-epd-v5-u133a.CEL
- XYrjg235-epd-v5-u133a.CEL
- XYrjg243-u133a.CEL
- XYrjg244-u133a.CEL
24.7MB FTP HTTP
group4.zip (7 files)
- XYrjg247-epy-u133a.CEL
- XYrjg250-epy-u133a.CEL
- XYrjg251-epy-u133a.CEL
- XYrjg252-epy-u133a.CEL
- XYrjg253-u133a.CEL
- XYrjg260-u133a.CEL
- XYrjg262-u133a.CEL
22.3MB FTP HTTP