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ALL Methylation Supplementary Table 4-8

List of highly correlated Refseq genes with upregulated FDR<0.05 and hypomethylated FDR<0.05 in MLLr_B

RefSeq Genes Annotation Cytoband Max Pearson Corr Estimate P Max Pearson Corr Max Pearson Corr Affy Probe GEP FC GEP FDR GEP Common Rank Max Pearson Corr HELP Probe MET Delta MET FDR
NM_000318 PXMP3 peroxisomal membrane protein 3, 35kDa chr8q21.1 0.544006828 3.84E-11 210296_s_at -1.598870603 0.008157522 785 / 12428 MSPI0406S00433478 -0.555789995 0.021037444
NM_001553 IGFBP7 insulin-like growth factor binding protein 7 chr4q12 0.54018042 5.59E-11 201162_at -8.096622166 2.63E-05 184 / 12428 MSPI0406S00232413 -0.736811381 0.00882502
NM_014899 RHOBTB3 Rho-related BTB domain containing 3 chr5q15 0.529437648 1.56E-10 202975_s_at -3.476752848 7.30E-11 25 / 12428 MSPI0406S00277663 -2.719987272 3.71E-15
NM_016562 TLR7 toll-like receptor 7 chrXp22.3 0.515079279 5.80E-10 220146_at -2.484723862 0.000957055 414 / 12428 MSPI0406S00987783 -2.06752525 6.47E-08
NM_003980 MAP7 microtubule-associated protein 7 chr6q23.3 0.485554334 7.21E-09 202890_at -3.654422915 3.02E-10 27 / 12428 MSPI0406S00339056 -3.267719298 4.34E-16
NM_017670 OTUB1 OTU domain, ubiquitin aldehyde binding 1 chr11q13.1 0.467821497 2.93E-08 201245_s_at -1.372410753 0.002540531 551 / 12428 MSPI0406S00568950 -0.446891691 0.001638519
NM_002319 LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4 chr7q22 0.450010468 1.11E-07 90610_at -1.53512795 0.000893043 401 / 12428 MSPI0406S00387615 -0.336160831 0.0103344
NM_003977 AIP aryl hydrocarbon receptor interacting protein chr11q13.3 0.444202973 1.68E-07 201782_s_at -1.233566884 0.040812296 1452 / 12428 MSPI0406S00572889 -0.302136322 0.040710864
NM_001134375 CCNJ cyclin J chr10pter-q26.12 0.43520177 3.17E-07 219470_x_at -1.386733492 0.045621327 1521 / 12428 MSPI0406S00529821 -0.792611407 0.007940939
NM_005582 CD180 CD180 molecule chr5q12 0.433635078 3.53E-07 206206_at -3.129620106 1.86E-08 52 / 12428 MSPI0406S00271573 -1.34328511 2.20E-05
NM_004119 FLT3 fms-related tyrosine kinase 3 chr13q12 0.431814525 4.00E-07 206674_at -2.308167878 0.023417321 1189 / 12428 MSPI0406S00647380 -1.46578287 3.45E-11
NM_003363 USP4 ubiquitin specific peptidase 4 (proto-oncogene) chr3p21.3 0.426662474 5.68E-07 202682_s_at -1.211404773 0.028826582 1300 / 12428 MSPI0406S00177614 -0.265820389 9.85E-05
NM_000856 GUCY1A3 guanylate cyclase 1, soluble, alpha 3 chr4q31.3-q33|4q31.1-q31.2 0.415632315 1.18E-06 221942_s_at -2.480625179 3.15E-05 190 / 12428 MSPI0406S00247758 -2.83621883 6.07E-32
NM_007022 CYB561D2 cytochrome b-561 domain containing 2 chr3p21.3 0.409356078 1.76E-06 209665_at -1.327316607 0.019851901 1108 / 12428 MSPI0406S00178547 -0.353840777 0.008440608
NM_012071 COMMD3 COMM domain containing 3 chr10pter-q22.1 0.402099061 2.79E-06 218048_at -1.413764479 0.00636195 734 / 12428 MSPI0406S00507118 -0.862762106 0.041607716
NM_005692 ABCF2 ATP-binding cassette, sub-family F (GCN20), member 2 chr7q36 0.400321697 3.11E-06 207622_s_at -1.398894978 0.049150888 1576 / 12428 MSPI0406S00403012 -0.302504287 0.022206331
NM_021165 FAM5B family with sequence similarity 5, member B chr1q24.1-q25.3 0.391873519 5.21E-06 214822_at -1.585405639 0.026947056 1271 / 12428 MSPI0406S00063949 -1.308675055 0.000398533
NM_024615 PARP8 poly (ADP-ribose) polymerase family, member 8 chr5q11.1 0.386523977 7.17E-06 219033_at -2.024356533 5.52E-05 224 / 12428 MSPI0406S00268523 -1.104655944 4.16E-05
NM_004364 CEBPA CCAAT/enhancer binding protein (C/EBP), alpha chr19q13.1 0.37959811 1.08E-05 204039_at -2.737047739 0.000286433 316 / 12428 MSPI0406S00886962 -0.753669477 0.017139581
NM_001556 IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta chr8p11.2 0.375433279 1.37E-05 211027_s_at -1.715199724 0.020328929 1116 / 12428 MSPI0406S00425766 -0.197761966 0.032119136
NM_002208 ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) chr17p13 0.359406261 3.33E-05 205055_at -1.627467433 0.003189973 596 / 12428 MSPI0406S00784823 -2.240820184 2.36E-11
NM_013450 BAZ2B bromodomain adjacent to zinc finger domain, 2B chr2q23-q24 0.343497731 7.69E-05 203080_s_at -1.590702649 0.028156528 1288 / 12428 MSPI0406S00137502 -2.635560462 1.74E-26
NM_018014 BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) chr2p16.1 0.341899778 8.35E-05 210347_s_at -1.668324072 0.000595779 371 / 12428 MSPI0406S00109277 -0.316260367 0.011183974
NM_001008709 PPP1CA protein phosphatase 1, catalytic subunit, alpha isoform chr11q13 0.334962673 0.000118444 200846_s_at -1.589260839 0.014172316 961 / 12428 MSPI0406S00572777 -0.305161467 0.032088704
NM_002486 NCBP1 nuclear cap binding protein subunit 1, 80kDa chr9q34.1 0.332890289 0.000131278 209520_s_at -1.330969996 0.015233194 989 / 12428 MSPI0406S00474163 -0.189316809 0.039276269
NM_000990 RPL27A ribosomal protein L27a chr11p15 0.329103817 0.00015813 212044_s_at -1.533580516 0.000996604 418 / 12428 MSPI0406S00553699 -0.482057064 0.00260657
NM_005940 MMP11 matrix metallopeptidase 11 (stromelysin 3) chr22q11.2|22q11.23 0.312398656 0.000349337 203878_s_at -1.774292848 0.000164256 276 / 12428 MSPI0406S00960095 -0.260235995 0.032247005
NM_005783 TXNDC9 thioredoxin domain containing 9 chr2q11.2 0.311313585 0.000367214 211758_x_at -1.321591176 0.031081595 1328 / 12428 MSPI0406S00120597 -0.354980647 0.045704606
NM_012167 FBXO11 F-box protein 11 chr2p16.3 0.303673087 0.000519065 203255_at -2.038063028 7.33E-07 91 / 12428 MSPI0406S00107104 -0.248654437 0.005482804
NM_023928 AACS acetoacetyl-CoA synthetase chr12q24.31 0.301545705 0.000570629 218434_s_at -1.848243391 0.013648301 951 / 12428 MSPI0406S00637965 -0.223067348 0.002888822
NM_001030288 SPN sialophorin chr16p11.2 0.30071867 0.000591917 216981_x_at -1.794051492 0.000225614 297 / 12428 MSPI0406S00753865 -0.264132861 0.047528657
NM_022128 RBKS ribokinase chr2p23.3 0.297755987 0.000674312 57540_at -1.635400294 0.008234319 788 / 12428 MSPI0406S00100213 -0.51311582 0.000225989
NM_001081438 LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4 chr19q13.4 0.297546445 0.000680521 210152_at -1.848783531 0.000535557 363 / 12428 MSPI0406S00906572 -1.003785714 0.002225928
NM_024334 TMEM43 transmembrane protein 43 chr3p25.1 0.295727127 0.000736677 217795_s_at -1.223283219 0.024031 1212 / 12428 MSPI0406S00167456 -0.346369773 0.039674467
NM_012408 ZMYND8 zinc finger, MYND-type containing 8 chr20q13.12 0.293805987 0.000800566 209049_s_at -1.623396051 0.002655335 559 / 12428 MSPI0406S00927995 -0.273952368 0.049640769
NM_001127207 SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 chr2q34-q35 0.287757913 0.001036319 218452_at -1.642933496 0.039155534 1431 / 12428 MSPI0406S00148581 -0.454179542 0.017719723
NM_021038 MBNL1 muscleblind-like (Drosophila) chr3q25 0.286257974 0.001103866 201153_s_at -2.789800458 4.23E-13 11 / 12428 MSPI0406S00201785 -0.363044557 0.000470115
NM_022166 XYLT1 xylosyltransferase I chr16p12.3 0.285996669 0.001116037 213725_x_at -2.194900879 3.55E-06 125 / 12428 MSPI0406S00746901 -0.389597823 0.00135686
NM_005680 TAF1B TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa chr2p25 0.285493035 0.001139841 216941_s_at -1.783371113 0.000159869 274 / 12428 MSPI0406S00092852 -0.389481981 0.026051913
NM_001111077 EZR ezrin chr6q25.2-q26 0.283240279 0.001252096 217230_at -1.706931233 0.004861191 670 / 12428 MSPI0406S00345716 -0.272387375 0.023621104
NM_004348 RUNX2 runt-related transcription factor 2 chr6p21 0.277939475 0.001557081 216994_s_at -2.015556115 0.000357257 331 / 12428 MSPI0406S00324469 -0.279031515 0.004232557
NM_006670 TPBG trophoblast glycoprotein chr6q14-q15 0.273404295 0.001870074 203476_at -2.005269849 0.010513265 853 / 12428 MSPI0406S00329444 -0.679306425 0.011329298
NM_000264 PTCH1 patched homolog 1 (Drosophila) chr9q22.3 0.270828794 0.002072253 209815_at -2.854292312 0.000329952 324 / 12428 MSPI0406S00473046 -0.34901333 0.009167568
NM_000962 PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) chr9q32-q33.3 0.266425258 0.002464266 215813_s_at -1.446961238 0.006175749 721 / 12428 MSPI0406S00481462 -0.272785457 0.000791715
NM_002033 FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) chr11q21 0.260972605 0.003041959 209892_at -1.431847238 0.026827515 1267 / 12428 MSPI0406S00582935 -0.501846309 0.002195903
NM_015080 NRXN2 neurexin 2 chr11q13 0.260693429 0.003074582 209983_s_at -2.248781412 0.011631759 892 / 12428 MSPI0406S00569826 -0.305681281 0.001109019
NM_000153 GALC galactosylceramidase chr14q31 0.257220827 0.003507535 204417_at -1.487057832 0.002224667 530 / 12428 MSPI0406S00685961 -0.915806507 0.000670288
NM_001145847 PROM1 prominin 1 chr4p15.32 0.25419846 0.003928146 204304_s_at -4.871155408 0.000191738 283 / 12428 MSPI0406S00224162 -0.886948452 0.023368954
NM_000534 PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) chr2q31-q33|2q31.1 0.25109713 0.004406258 213677_s_at -1.368278285 0.020429487 1118 / 12428 MSPI0406S00142784 -0.188086399 0.007683098
NM_003794 SNX4 sorting nexin 4 chr3q21.2 0.237924973 0.007069303 212652_s_at -1.247693057 0.024757241 1231 / 12428 MSPI0406S00193821 -0.328711137 0.010758999
NM_004899 BRE brain and reproductive organ-expressed (TNFRSF1A modulator) chr2p23.2 0.23782307 0.007094535 205550_s_at -1.288200318 0.012760144 923 / 12428 MSPI0406S00100215 -1.609569583 6.48E-05
NM_002961 S100A4 S100 calcium binding protein A4 chr1q21 0.235565688 0.007674362 203186_s_at -2.81424278 0.000727435 382 / 12428 MSPI0406S00056069 -0.484993736 0.002815514
NM_152739 HOXA9 homeobox A9 chr7p15-p14 0.232351252 0.008572365 209905_at -5.853754671 9.17E-15 10 / 12428 MSPI0406S00363159 -0.407558742 0.018864767
NM_001031848 SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 chr18q21.3 0.229837551 0.009338026 206034_at -1.671578851 0.00465105 661 / 12428 MSPI0406S00853335 -1.291268106 0.001205448
NM_014415 ZBTB11 zinc finger and BTB domain containing 11 chr3q12.3 0.229014336 0.009601555 204847_at -1.295202373 0.005976789 715 / 12428 MSPI0406S00189262 -0.327369368 0.000166709
NM_005013 NUCB2 nucleobindin 2 chr11p15.1-p14 0.227802224 0.010001501 203675_at -1.461744869 0.028826582 1301 / 12428 MSPI0406S00556387 -0.230597167 0.015013535
NM_001130721 ELOVL6 ELOVL family member 6, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast) chr4q25 0.225029811 0.010971831 204256_at -1.534743582 0.009282753 822 / 12428 MSPI0406S00240343 -0.657794592 0.02291548
NM_001002810 PDE4DIP phosphodiesterase 4D interacting protein chr1q12 0.222445367 0.011949821 213388_at -1.681176027 0.027207592 1276 / 12428 MSPI0406S00052768 -1.225695007 0.028743014
NM_001164410 CDK5 cyclin-dependent kinase 5 chr7q36 0.217061398 0.014235255 204247_s_at -1.686735213 0.036628115 1406 / 12428 MSPI0406S00402809 -0.346577185 0.046198835
NM_001466 FZD2 frizzled homolog 2 (Drosophila) chr17q21.1 0.215782795 0.014830944 210220_at -1.814684516 0.038132903 1418 / 12428 MSPI0406S00809345 -0.288953163 0.024248228
NM_005731 ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa chr2q36.1 0.213348601 0.0160252 208679_s_at -1.311057516 0.002382992 540 / 12428 MSPI0406S00149290 -0.380519467 0.049239815
NM_014845 FIG4 FIG4 homolog (S. cerevisiae) chr6q21 0.208556007 0.018622417 203656_at -1.445471509 0.000416376 341 / 12428 MSPI0406S00334298 -0.165513363 0.016915006
NM_001620 AHNAK AHNAK nucleoprotein chr11q12.2 0.207653673 0.019150132 211986_at -2.151885142 0.026190245 1255 / 12428 MSPI0406S00567911 -0.856792499 1.80E-05
NM_003745 SOCS1 suppressor of cytokine signaling 1 chr16p13.13 0.203806463 0.021547541 213337_s_at -1.484884415 0.010513265 852 / 12428 MSPI0406S00742806 -0.563033346 0.000102634
NM_001042540 NCBP2 nuclear cap binding protein subunit 2, 20kDa chr3q29 0.194000056 0.028855116 201517_at -1.469311487 0.003724889 625 / 12428 MSPI0406S00213768 -0.164299792 0.020668406
NM_002794 PSMB2 proteasome (prosome, macropain) subunit, beta type, 2 chr1p34.2 0.189006718 0.033323953 201404_x_at -1.521105716 0.01089017 870 / 12428 MSPI0406S00029189 -0.312612653 0.001851063
NM_003599 SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) chr6p21.1-p21.3 0.18844549 0.033860986 206506_s_at -1.891152585 0.000541154 365 / 12428 MSPI0406S00324450 -0.476768321 0.035994167
NM_002643 PIGF phosphatidylinositol glycan anchor biosynthesis, class F chr2p21-p16 0.182818275 0.03966136 205078_at -1.45683041 0.009470815 827 / 12428 MSPI0406S00106399 -0.317643044 0.018359408
NM_001007225 IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 chr3q27.2 0.182721973 0.039767457 218847_at -4.84128711 5.37E-07 86 / 12428 MSPI0406S00209229 -1.826257204 6.34E-06
NM_000378 WT1 Wilms tumor 1 chr11p13 0.1789804 0.044077642 206067_s_at -3.813123699 4.48E-08 57 / 12428 MSPI0406S00559240 -0.402367939 1.30E-05
NM_003640 IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein chr9q31 0.178526758 0.044625764 202491_s_at -1.394496255 0.00333932 609 / 12428 MSPI0406S00476944 -0.252546654 0.003381056
NM_080548 PTPN6 protein tyrosine phosphatase, non-receptor type 6 chr12p13 0.17750407 0.045882306 206687_s_at -2.329201851 1.40E-06 102 / 12428 MSPI0406S00600954 -0.302454339 0.000918434
NM_016167 NOL7 nucleolar protein 7, 27kDa chr6p23 0.176403046 0.047267872 213838_at -1.498041261 0.000929131 405 / 12428 MSPI0406S00309022 -0.229948109 0.03901158