Publications

(*indicates corresponding author)

Su. G.X., Yan, B.* Nano-Combinatorial Chemistry Strategy for Nanotechnology Research. J Comb Chem 2010, in press.

Zhang, Q., Zhou, H.Y., Zhai, S.M., Yan, B.* Natural Product–Inspired Synthesis of Thiazolidine and Thiazolidinone Compounds and Their Anticancer Activities. Curr Pham Design 2010, in press.

Wang, F., Jiao, P.F., Qi, M.H., Frezza, M., Dou, Q. P.*, Yan, B.* Turning Tumor-Promoting Copper into an Anti-Cancer Weapon via High-Throughput chemistry. Curr Med Chem 2010, in press.

Zhai, S.M., Yang, L., Cui, Q.Z.C., Sun, Y., Dou, Q.P.*, Yan, B.* Tumor Cellular Proteasome Inhibition and Growth Suppression by 8-Hydroxylquinoline and Clioquinol Requires Their Capabilities to Bind Copper and Transport Copper into Cells. J Biological Inorganic Chemistry 15(2), 259-269, 2010.

Zhou, H.Y., Zhang, W., Yan, B.* Use Cyclohexylisocyanide and Methyl 2-Isocyanoacetate as Convertible Isocyanides for Microwave-Assisted Fluorous Synthesis of 1,4-Benzodiazepine-2,5-Dione Library. J Comb Chem 12(1), 206-214, 2010.

Zhang, B., Yan, B.* Analytical Strategies for Characterizing Nanoparticles Surface Chemistry. Anal Bioanal Chem, 396(3), 973-982, 2010.

Mu, Q.X., Broughton, D.L., Yan, B.* Endosomal leakage and Nuclear Translocation of Multiwalled Carbon Nanotubes: Developing a Model for Cell Uptake. Nano Letters 9(12), 4370-4375, 2009.

Liu, A.F., Zhou, H.Y., Su, G.X., Zhang, W., Yan, B.* Microwave-Assisted Fluorous Synthesis of 1,4-Benzodiazepine-2,5-Dione Library. J Comb Chem 11(6), 1083-1093, 2009.

Milacic, V., Jiao, P.F., Zhang, B., Yan, B.*, Dou, Q.P.* Novel 8-Hydroxylquinoline Analogs Induce Copper-Dependent Proteasome Inhibition and Cell Death in Human Breat Cancer Cells. International Journal of Oncology 35(6), 1481-1491, 2009.

Luo, M.* and Yan, B.* A Simple Synthesis of Octaphenylcyclotetra(Siloxane). Tetrahedron Letters 50(37), 5208-5209, 2009.

Mu, Q.X., Du, G.Q., Chen, T.S., Zhang, B., Yan, B.* Suppression of Human Bone Mophorgenetic Protein (BMP) Signaling by Carboxylated Single-Walled Carbon Nanotubes. ACS Nano 3(5), 1139-1144, 2009.

Zhang, B., Xing, Y.H., Zhou, H.Y., Li, Z.W., Mu, Q.X., Yan, B.* Functionalized Carbon Nanotubes Specifically Bind to Chymotrypsin Catalytic Site and Regulate its Enzymatic Function. Nano Letters 9(6), 2280-2284, 2009.

Zhang, Q., Feng, W., Zhou, H.Y., Yan, B.* Advances in Preclinical Small Molecules for the Treatment of Non-Small Cell Lung Cancer. Expert Opinion on Therapeutic Patents 19(6), 731-751, 2009.

Guangbo Qu, Yuhong Bai, Yi Zhang, Qing Jia, Weidong Zhang, Bing Yan*. The effect of multiwalled carbon nanotube agglomeration on their accumulation in and damage to organs in mice. Carbon, 47, 2060-2069, 2009.

Qingxin Mu, Zhenwei Li, Xi Li, Sanjay R. Mishra, Bin Zhang, Zhikun Si, Lei Yang, Wei Jiang, Bing Yan*. Characterization of Protein Clusters of Diverse Magnetic Nanoparticles and Their Dynamic Interactions with Human Cells. J. Phys. Chem. C. 113 (14), 5390–5395, 2009.

Ma, X.F., Shi, R.R., Zhang, B., Yan, B.* Kinetics of Resin-Supported Mitsunobu Esterification and Etherification Reactions. J Comb Chem. 11 (3) 438-445, 2009.

Du, F.F., Zhou, H.Y., Chen, L.X., Zhang, B., Yan, B.* Structure Elucidation of Nanoparticle-Bound Organic Molecules by 1H NMR. Trends in Anal. Chem. 28(1), 88-95, 2009.

Zhou, H.Y., Du, F.F., Li, X., Zhang, B., Li, W., Yan, B.* Characterization of Organic Molecules Attached to Gold Nanoparticle Surface Using High Resolution Magic Angle Spinning 1H NMR. J. Phys. Chem. C., 112 (49) 19360-19366, 2008.

Yu, Y.M., Zhang, Q., Mu, Q.X., Zhang, B., Yan, B.* Exploring the Immunotoxicity of Carbon Nanotubes. Nanoscale Research Letters 3, 271-277, 2008.

Lemoff, A. and Yan, B.* Dual Detection Approach to a More Accurate Measure of Relative Purity in High-Throughput Characterization of Compound Collections. J Comb Chem 10(5), 746-751, 2008.

Qi M, Zhou H, Ma X, Zhang B, Jefferies C, Yan B.* Feasibility of a Self-Calibrated LC/MS/UV Method to Determine the Absolute Amount of Compounds in Their Storage and Screening Lifecycle. J Comb Chem 10 (2), 162-165, 2008.

Zhou H, Mu Q, Gao N, Liu A, Xing Y, Gao S, Zhang Q, Qu G, Chen Y, Liu G, Zhang B, Yan B*. A Nano-Combinatorial Library Strategy for the Discovery of Nanotubes with Reduced Protein-Binding, Cytotoxicity, and Immune Response. Nano Lett 8(3), 859-865, 2008. 

Zhou H, Wu S, Zhai S, Liu A, Sun Y, Li R, Zhang Y, Ekins S, Swaan PW, Fang B, Zhang B, Yan B*. Design, Synthesis, Cytoselective Toxicity, Structure-Activity Relationships, and Pharmacophore of Thiazolidinone Derivatives Targeting Drug-Resistant Lung Cancer Cells. J Med Chem 51, 1242-1251, 2008.

Mu Q, Liu W, Xing Y, Zhou H, Li Z, Zhang Y, Ji L, Wang F, Si Z, Zhang B, Yan B*. Protein Binding by Functionalized Multiwalled Carbon Nanotubes Is Governed by the Surface Chemistry of Both Parties and the Nanotube Diameter. J Phys Chem C 112(9), 3300-3307, 2008.

Zhang B, Li X, Yan B*. Advances in HPLC detector-towards universal detection. Anal Bioanal Chem 390(1), 299-301, 2008.

Zhou H, Liu A, Li X, Ma X, Feng W, Zhang W, Yan B*. Microwave-Assisted Fluorous Synthesis of 2-Aryl-Substituted 4-Thiazolidinone and 4-Thiazinanone Libraries. J Comb Chem 10(2), 303-312, 2008.

Yu Z, Wang F, Milacic V, Li X, Cui QC, Zhang B, Yan B*,  Dou QP.* Evaluation of copper-dependent proteasome-inhibitory And apoptosis-inducing activities of novel Pyrrolidine dithiocarbamate analogues. Int J Mol Med 20: 919-925, 2007.

Xu P, Qiu JH, Zhang YN, Chen J, Wang PG, Yan B, Song J, Xi Ri M, Deng ZX, Ma CQ. Efficient whole-cell biocatalytic synthesis of N-acetyl-D-neuraminic acid. Adv Syn Cat 349(10), 1614-1618, 2007.

Chen D, Cui QC, Yang H, Barrea RA, Sarkar FH, Sheng S, Yan B, Reddy GPV, Dou QP. Cliquinol, a Therapeutic Agent for Alzheimer’s Disease, Has Proteasome-inhibitory, Apoptosis-inducing and Anti-tumor Activities in Human Prostate Cancer Cells and Xenografts. Cancer Res 67(4):1636-44, 2007.

Zhai S, Liu W, Yan B.*   Recent patents on treatment of severe acute respiratory syndrome (SARS). Recent Patents on Anti-Infective Drug Discovery 2(1), 1-10, 2007.

Chen L, Choo J, Yan B. The microfabricated electrokinetic pump: a potential promising drug delivery technique. Expert Opin Drug Deliv 4(2):119-129, 2007.

Yan B*, Shi R, Zhang B, Kshirsagar T. A Kinetic Study of Product Cleavage Reactions from the Solid Phase by a Biocompatible and Removable Cleaving Reagent, HCl. J Combi Chem 9(4), 684-689, 2007.

Yan B*, Zhao J, Leopold K, Zhang B, Jiang G. The Structure Dependent Response of Chemiluminescence Nitrogen Detector (CLND) for Organic Compounds with Adjacent Nitrogen Atoms Connected by a Single Bond. Anal Chem 79 (2) 718-726, 2007.

Landis-Piwowar KR, Milacic V, Chen D, Yang H, Zhao ZY, Chan TH, Yan B, Dou QP. Discovering novel anticancer drugs and chemo-sensitizers by using the proteasome as a potential target. Drug Resistance Update 9, 263-273, 2006.

Cheng X, Yan B, Gao L, Tang H, Fan Y, Anderson SN, Affleck R, Burns D. Compound transfer efficiency from polystyrene surfaces-application to microarrayed compound screening. J Biomolecular Screening 10(4), 293-303, 2005.

Irving M, Krueger CA, Wade JV, Hodges JC, Leopold K, Chan C, Shaqair S, Shornikov A, Stock M, Collins N, Yan B*. High-Throughput Purification of Combinatorial Libraries II: Automated Separation of Single Diastereomers from a 1920-Member 4-Amidopyrrolidinone Library. J Combi Chem 6, 478-486, 2004.

Yan B*, Collins N, Wheatley J, Irving M, Leopold K, Chan C, Shornikov A, Fang L, Lee A, Stock M, Zhao J. High-Throughput Purification of Combinatorial Libraries I: A High-Throughput Purification System Using an Accelerated Retention Window Approach. J Combi Chem 6, 255-261, 2004.

Yan B*, Fang L, Irving M, Zhang S, Boldi AM, Woolard F, Johnson CR, Kshirsagar T, Figliozzi GM, Krueger CA, Collins N. Quality Control in Combinatorial Chemistry: Determination of the Quantity, Purity, and Quantitative Purity of Compounds in Combinatorial Libraries. J Combi Chem 5(5), 547-559, 2003.

Yan B*. Single bead analysis in combinatorial chemistry. Current Opinion in Chemical Biology 6, 328-332, 2002.
Fang L, Demee M, Sierra T, Kshirsagar T, Celebi A, Yan B*. Kinetic Study of Amine Cleavage Reactions of Various Resin-Bound Thiophenol Esters from Marshall Linker. J Combi Chem 4, 362-368, 2002.

Cournoyer JJ, Kshirsagar T, Fantauzzi PP, Figliozzi GM, Makdessian T, Yan B*. A Color Test for the Detection of Resin-Bound Aldehyde in Solid-Phase Combinatorial Synthesis. J Combi Chem 4, 120-124, 2002.

Yan B*, Yan H. Combination of Single Bead FTIR and Chemometrics in Combinatorial Chemistry: Application of Multivariate Calibration Method in the Monitoring of Solid Phase Organic Synthesis. J Combi Chem 3, 78-84, 2001.

Yan B*, Nguyen N, Liu L, Holland G, Raju B. Kinetic Comparison of Trifluoroacetic Acid Cleavage Reactions of Resin-Bound Carbamates, Ureas, Secondary Amides, and Sulfonamides from Benzyl-, Benzhydryl-, and Indole-Based Linkers. J Comb Chem 2(1) 66-74, 2000.

Yan B*, Liu L, Astor CA, Tang Q. Determination of the Absolute Amount of Resin-Bound Hydroxyl or Carboxyl Groups for the Optimization of Solid-Phase Combinatorial and Parallel Organic Synthesis. Anal Chem 71(20) 4564-4571, 1999.

Yan B*, Martin PC, Lee J. Single Bead Fluorescence Microspectroscopy: Detection of Self-Quenching in Fluorescence-Labeled Resin Beads. J Combin Chem 1, 78-81, 1999.

Yan B*. Monitoring the progress and the yield of solid-phase organic reactions directly on resin supports. Acct Chem Res 31, 621-630, 1998.

Yan B*, Sun Q. Crucial factors regulating site-interactions in resin supports determined by single bead IR. J Org Chem 63, 55-58, 1998.

Yan B*, Li W. Rapid fluorescence determination of the absolute amount of aldehyde and ketone groups on resin supports. J Org Chem 62, 9354-9357, 1997.

Yan B, Spudich EN, Sheves M, Spudich JL. Complexation of the signal transducing protein HtrI to sensory rhodopsin I and its effect on thermodynamics of signaling state deactivation. J Phys Chem 101, 109-113, 1997.

Yan B*, Sun Q, Wareing JR, Jewell CF. Real-time Monitoring of the Catalytic Oxidation of Alcohols on Resin Supports by Single Bead FTIR Microspectroscopy. J Org Chem 61, 8765-8770, 1996.

Yan B*, Fell JB, Kumaravel G. Progression of organic reactions on resin supports monitored by single bead FTIR microspectroscopy. J Org Chem 61, 7467-7472, 1996.

Yan B*, Spudich JL, Mazur P, Vunnam S, Derguini F, Nakanishi K. Spectral tuning in bacteriorhodopsin in the absence of counterion and coplanarization effects. J Biol Chem 270, 29668-29670, 1995.

Yan B, Kumaravel G, Anjaria H, Wu A, Petter RC, Jewell CF, Wareing J. Infrared spectrum of a single resin bead for real-time monitoring of solid-phase reactions. J Org Chem 60, 5736-5738, 1995.

Yan B, Xie A, Nienhaus GU, Katsuta Y, Spudich JL. Steric constraints in the retinal binding pocket of sensory rhodopsin I. Biochemistry 32, 10224-10232, 1993.

Ratto GM, Robinson DW, Yan B, McNaughton PA. Development of the light response in neonatal mammalian rods. Nature 351, 654-657, 1991.

Yan B, Nakanishi K, Spudich JL. Mechanism of activation of sensory rhodopsin I: evidence for a steric trigger. Proc Natl Acad Sci USA 88, 9412-9416, 1991.

Yan B, Takahashi T, Johnson R, Spudich JL. Identification of signaling states of a sensory receptor by modulation of lifetimes of stimulus-induced conformations: the case of sensory rhodopsin II. Biochemistry 30, 10686-10692, 1991.