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Northcott Lab: About Us

Welcome to the lab of Paul A. Northcott, PhD

Northcott Lab Group

The Northcott Lab aims to fully characterize the molecular, cellular, and biological basis of medulloblastoma, one of the most prevalent types of malignant childhood brain cancer. The foundation of our work is based upon recent comprehensive next-generation genomic analyses through which we have discovered the genes, pathways, and molecular processes recurrently altered in patients with medulloblastoma. Our current focus is to summarize these somatic alterations in the context of medulloblastoma subgroups and functionally validate candidate driver genes and pathways using a variety of technically advanced in vivo methodologies. In addition, we are working closely with the Division of Neuro-Oncology at St. Jude to improve understanding of how specific genomic variants correlate with the demographic and clinical features of medulloblastoma patients treated on clinical trials conducted at St. Jude Children’s Research Hospital. Collectively, these studies will lead to a better understanding of the molecular and cellular origins of medulloblastoma and translate to improved stratification and treatment options for patients and their families.

Interested in joining the Northcott lab?

Currently, multiple staff and postdoctoral positions are available. View Open Postdoctoral Positions or contact Paul Northcott for more information.

News and Information

St. Jude scientist named Pew-Stewart Scholar: Paul Northcott selected for support as a promising early-career scientist focused on cancer research.
St. Jude Children’s Research Hospital News Release. June 9, 2016.

Read the latest research article with Paul Northcott as co-leader of the study
Active medulloblatoma enhancers reveal subgroup-specific cellular origins
Nature January 27, 2016. Epub ahead of print. doi: 10.1038/nature16546.

Honors and Awards

  • 2016 Sontag Foundation Distinguished Scientist Award
  • 2016 AACR NextGen Grant for Transformative Cancer Research
  • 2016 Pew-Stewart Scholar for Cancer Research
  • 2015 V Foundation V Scholar Award
  • 2014 Pediatric Basic Science Award (Society for Neuro-Oncology (SNO) Meeting)
  • 2014 German Cancer Research Center (DKFZ) Alumni Award
  • 2013 Lap-Chee Tsui Publication Award for 2012 (CIHR Institute of Genetics)
  • 2012 Roman Herzog PostDoctoral Fellowship (Hertie Foundation)
  • 2011 Stuart Alan Hoffman Memorial Prize (University of Toronto)
  • 2011 Keystone Symposia Future of Science Fund Scholarship (Changing Landscape of the Cancer Genome Meeting)