Welcome to the lab of Xiang Chen, PhD
The Chen laboratory is focused on development and application of novel analytical methods for high-throughput, multi-platform omics data in delineating genetic alterations and epigenetic deregulations in pediatric solid tumors. We are also interested in developing experimental models to understand functional roles in tumorigenesis for candidate cancer driver genes emerged after critical evaluation of omics data.
DNA methylation is an important mechanism for establishing a cell’s developmental identity. We developed a recursive partitioning approach that is robust to technical artifacts from single-nucleotide polymorphisms at the CpG dinucleotides (CpG-SNPs) and is a powerful method to reveal co-methylation blocks using whole-genome bisulfide sequencing.