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Supplementary Information

Gene Expression Profiling of Pediatric Acute Myelogenous Leukemia

Section III: Genetic Subtype Discriminating Genes

Table S7. Top 100 probe sets selected by SAM  for t(8;21)[AML1-ETO]

  U133 probe set Gene description Symbol Location GenBank reference UniGene reference SAM d-score t(8;21) Above/ Below mean Fold change
1 205529_s_at core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related CBFA2T1 Chr:8q22 NM_004349 Hs.90858 30.0 Above 25.0
2 205528_s_at core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related CBFA2T1 Chr:8q22 X79990 Hs.90858 25.2 Above 34.3
3 206940_s_at POU domain, class 4, transcription factor 1 POU4F1 Chr:13q21.1-q22 NM_006237 Hs.458303 17.0 Above 32.2
4 211341_at POU domain, class 4, transcription factor 1 POU4F1 Chr:13q21.1-q22 L20433 Hs.458303 16.0 Above 75.7
5 216831_s_at core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related CBFA2T1 Chr:8q22 AF018283 Hs.90858 13.2 Above 36.4
6 212496_s_at KIAA0876 protein KIAA0876 Chr:19p13.3 BE256900 Hs.301011 13.1 Above 3.1
7 206622_at thyrotropin-releasing hormone TRH Chr:3q13.3-q21 NM_007117 Hs.182231 12.3 Above 13.7
8 212097_at caveolin 1, caveolae protein, 22kDa CAV1 Chr:7q31.1 AU147399 Hs.74034 11.6 Above 16.6
9 204811_s_at calcium channel, voltage-dependent, alpha 2/delta subunit 2 CACNA2D2 Chr:3p21.3 NM_006030 Hs.389415 11.3 Above 6.9
10 205173_x_at CD58 antigen, (lymphocyte function-associated antigen 3) CD58 Chr:1p13 NM_001779 Hs.75626 11.3 Above 3.4
11 211744_s_at CD58 antigen, (lymphocyte function-associated antigen 3) CD58 Chr:1p13 BC005930 Hs.75626 10.9 Above 3.6
12 211685_s_at neurocalcin delta NCALD Chr:8q22-q23 AF251061 Hs.90063 10.4 Above 2.9
13 216942_s_at CD58 antigen, (lymphocyte function-associated antigen 3) CD58 Chr:1p13 D28586 Hs.75626 10.2 Above 3.8
14 206398_s_at CD19 antigen CD19 Chr:16p11.2 NM_001770 Hs.96023 10.0 Above 4.8
15 213194_at roundabout, axon guidance receptor, homolog 1 (Drosophila) ROBO1 Chr:3p14.2 NM_002941 Hs.301198 9.9 Above 15.0
16 206187_at prostaglandin I2 (prostacyclin) receptor (IP) PTGIR Chr:19q13.3 NM_000960 Hs.458324 9.7 Above 4.3
17 210010_s_at solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 SLC25A1 Chr:22q11.21 U25147 Hs.111024 9.5 Above 2.4
18 218858_at hypothetical protein FLJ12428 FLJ12428 Chr:8q24.12 NM_022783 Hs.87729 9.2 Above 2.8
19 212495_at KIAA0876 protein KIAA0876 Chr:19p13.3 BE256900 Hs.301011 9.2 Above 2.3
20 208116_s_at mannosidase, alpha, class 1A, member 1 MAN1A1 Chr:6q22 NM_005907 Hs.255149 9.1 Above 4.1
21 221760_at mannosidase, alpha, class 1A, member 1 MAN1A1 Chr:6q22 BG287153 Hs.255149 9.0 Above 4.6
22 204073_s_at chromosome 11 open reading frame 9 C11orf9 Chr:11q12-q13.1 NM_013279 Hs.184640 8.9 Above 3.9
23 219686_at gene for serine/threonine protein kinase HSA250839 Chr:4p16.2 NM_018401 Hs.58241 8.9 Above 5.4
24 206855_s_at hyaluronoglucosaminidase 2 HYAL2 Chr:3p21.3 NM_003773 Hs.76873 8.9 Above 1.9
25 218613_at hypothetical protein DKFZp761K1423 DKFZp761K1423 Chr:8p22 NM_018422 Hs.236438 8.8 Above 4.1
26 210744_s_at interleukin 5 receptor, alpha IL5RA Chr:3p26-p24 M75914 Hs.68876 8.6 Above 9.9
27 216832_at core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related CBFA2T1 Chr:8q22 AF018283 Hs.90858 8.5 Above 2.5
28 203355_s_at ADP-ribosylation factor guanine nucleotide factor 6 EFA6R Chr:8pter-p23.3 NM_015310 Hs.408177 8.3 Above 5.5
29 204698_at interferon stimulated gene 20kDa ISG20 Chr:15q26 NM_002201 Hs.105434 8.2 Above 6.8
30 218352_at regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 RCBTB1 Chr:13q14 NM_018191 Hs.58452 8.2 Above 2.4
31 204990_s_at integrin, beta 4 ITGB4 Chr:17q11-qter NM_000213 Hs.85266 8.2 Above 4.2
32 211517_s_at interleukin 5 receptor, alpha IL5RA Chr:3p26-p24 M96651 Hs.68876 8.2 Above 8.5
33 201281_at adhesion regulating molecule 1 ADRM1 Chr:20q13.33 NM_007002 Hs.90107 8.1 Above 2.1
34 33304_at interferon stimulated gene 20kDa ISG20 Chr:15q26 U88964 Hs.105434 8.1 Above 2.7
35 204086_at preferentially expressed antigen in melanoma PRAME Chr:22q11.22 NM_006115 Hs.30743 8.0 Above 4.5
36 214853_s_at pygopus 2 PYGO2 Chr:1q22 AI091079 Hs.172084 8.0 Above 2.1
37 203065_s_at caveolin 1, caveolae protein, 22kDa CAV1 Chr:7q31.1 NM_001753 Hs.74034 7.8 Above 8.2
38 222067_x_at histone 1, H2bd HIST1H2BD Chr:6p21.3 AL353759 Hs.180779 7.7 Above 3.5
39 218825_at EGF-like-domain, multiple 7 EGFL7 Chr:9q34.3 NM_016215 Hs.91481 7.6 Above 3.1
40 217795_s_at hypothetical protein MGC3222 MGC3222 Chr:3p25.1 W74580 Hs.130330 7.6 Above 1.5
41 206090_s_at disrupted in schizophrenia 1 DISC1 Chr:1q42.1 NM_018662 Hs.26985 7.6 Above 1.8
42 209543_s_at CD34 antigen CD34 Chr:1q32 M81104 Hs.374990 7.6 Above 3.5
43 203859_s_at paralemmin PALM Chr:19p13.3 NM_002579 Hs.78482 7.3 Above 2.2
44 219478_at WAP four-disulfide core domain 1 WFDC1 Chr:16q24.3 NM_021197 Hs.36688 7.2 Above 3.3
45 205513_at transcobalamin I (vitamin B12 binding protein, R binder family) TCN1 Chr:11q11-q12 NM_001062 Hs.2012 7.2 Above 5.0
46 219911_s_at solute carrier family 21 (organic anion transporter), member 12 SLC21A12 Chr:20q13.33 NM_016354 Hs.235782 7.1 Above 2.8
47 212706_at DNA directed RNA polymerase II polypeptide J-related gene POLR2J2 Chr:7q11.22 AB011110 Hs.406505 7.0 Above 2.1
48 222061_at CD58 antigen, (lymphocyte function-associated antigen 3) CD58 Chr:1p13 AA700015 Hs.75626 6.9 Above 3.5
49 219201_s_at twisted gastrulation homolog 1 (Drosophila) TWSG1 Chr:18p11.3 NM_020648 Hs.247302 6.7 Above 5.8
50 204494_s_at DKFZP434H132 protein DKFZP434H132 Chr:15q23 AW516789 Hs.17936 -6.6 Below 2.6
51 212370_x_at hypothetical protein FLJ10824 FLJ10824 Chr:10q11.23 AL080183 Hs.375174 6.6 Above 1.7
52 216356_x_at BAI1-associated protein 3 BAIAP3 Chr:16p13.3 AB018277 Hs.458427 6.6 Above 3.0
53 204495_s_at DKFZP434H132 protein DKFZP434H132 Chr:15q23 NM_015492 Hs.17936 -6.5 Below 2.8
54 206147_x_at sex comb on midleg-like 2 (Drosophila) SCML2 Chr:Xp22 NM_006089 Hs.171558 6.5 Above 1.7
55 206726_at prostaglandin D2 synthase, hematopoietic PGDS Chr:4q22.3 NM_014485 Hs.128433 6.5 Above 4.0
56 212573_at KIAA0830 protein KIAA0830 Chr:11q21 AF131747 Hs.167115 6.4 Above 1.8
57 209911_x_at histone 1, H2bd HIST1H2BD Chr:6p21.3 BC002842 Hs.180779 6.4 Above 2.3
58 219255_x_at interleukin 17 receptor B IL17RB Chr:3p21.1 NM_018725 Hs.5470 6.4 Above 2.9
59 212492_s_at KIAA0876 protein KIAA0876 Chr:19p13.3 AW237172 Hs.301011 6.3 Above 2.5
60 218332_at brain expressed, X-linked 1 BEX1 Chr:Xq21-q23 NM_018476 Hs.334370 6.3 Above 4.5
61 219132_at pellino homolog 2 (Drosophila) PELI2 Chr:14q21 NM_021255 Hs.44038 6.3 Above 2.1
62 201839_s_at tumor-associated calcium signal transducer 1 TACSTD1 Chr:2p21 NM_002354 Hs.692 6.3 Above 4.2
63 201721_s_at Lysosomal-associated multispanning membrane protein-5 LAPTM5 Chr:1p34 NM_006762 Hs.436200 -6.2 Below 2.2
64 218899_s_at brain and acute leukemia, cytoplasmic BAALC Chr:8q22.3 NM_024812 Hs.169395 6.2 Above 3.6
65 219890_at C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 5 CLECSF5 Chr:7q33 NM_013252 Hs.126355 6.1 Above 2.9
66 209137_s_at ubiquitin specific protease 10 USP10 Chr:16q24.1 BC000263 Hs.78829 6.1 Above 1.5
67 218742_at protein related to Narf HPRN Chr:16p13.3 NM_022493 Hs.22158 6.1 Above 2.4
68 218205_s_at MAP kinase-interacting serine/threonine kinase 2 MKNK2 Chr:19p13.3 NM_017572 Hs.512094 6.0 Above 1.7
69 204319_s_at regulator of G-protein signalling 10 RGS10 Chr:10q25 NM_002925 Hs.82280 6.0 Above 2.3
70 211068_x_at KIAA0592 protein KIAA0592 Chr:10q11.1 BC006456 Hs.439367 6.0 Above 1.6
71 203379_at ribosomal protein S6 kinase, 90kDa, polypeptide 1 RPS6KA1 Chr:3 NM_002953 Hs.149957 -6.0 Below 2.0
72 218557_at Nit protein 2 NIT2 Chr:3q12.3 NM_020202 Hs.439152 5.9 Above 1.7
73 208712_at cyclin D1 (PRAD1: parathyroid adenomatosis 1) CCND1 Chr:11q13 M73554 Hs.371468 5.9 Above 4.2
74 214349_at Homo sapiens transcribed sequences --- --- AV764378 Hs.464403 5.9 Above 3.9
75 204929_s_at vesicle-associated membrane protein 5 (myobrevin) VAMP5 Chr:2p11.2 NM_006634 Hs.74669 5.9 Above 2.3
76 208546_x_at histone 1, H2bh HIST1H2BH Chr:6p21.3 NM_003524 Hs.247815 5.9 Above 2.6
77 220307_at natural killer cell receptor 2B4 CD244 Chr:1q23.1 NM_016382 Hs.157872 5.9 Above 2.2
78 202081_at immediate early protein ETR101 Chr:19p13.13 NM_004907 Hs.737 5.8 Above 2.0
79 202117_at Rho GTPase activating protein 1 ARHGAP1 Chr:11p12-q12 BG468434 Hs.138860 -5.8 Below 1.6
80 214946_x_at hypothetical protein FLJ10824 FLJ10824 Chr:10q11.23 AV728658 Hs.375174 5.8 Above 1.9
81 202006_at protein tyrosine phosphatase, non-receptor type 12 PTPN12 Chr:7q11.23 NM_002835 Hs.62 -5.8 Below 2.2
82 208490_x_at histone 1, H2bf HIST1H2BF Chr:6p21.3 NM_003522 Hs.182137 5.8 Above 2.8
83 208885_at lymphocyte cytosolic protein 1 (L-plastin) LCP1 Chr:13q14.3 J02923 Hs.381099 -5.7 Below 2.5
84 215411_s_at chromosome 6 open reading frame 4 C6orf4 Chr:6q21 AL008730 Hs.437508 5.7 Above 2.3
85 221581_s_at Williams-Beuren syndrome chromosome region 5 WBSCR5 Chr:7q11.23 AF257135 Hs.56607 -5.7 Below 10.6
86 208091_s_at hypothetical protein DKFZp564K0822 DKFZP564K0822 Chr:7p11.2 NM_030796 Hs.4750 -5.7 Below 3.2
87 219752_at RAS protein activator like 1 (GAP1 like) RASAL1 Chr:12q23-q24 NM_004658 Hs.198312 5.7 Above 2.1
88 209539_at Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 ARHGEF6 Chr:Xq26 D25304 Hs.372800 5.7 Above 1.6
89 221257_x_at hypothetical protein SP329 SP329 Chr:5q33.1 NM_030793 Hs.163825 5.7 Above 1.8
90 208523_x_at histone 1, H2bi HIST1H2BI Chr:6p21.3 NM_003525 Hs.182140 5.7 Above 3.2
91 201720_s_at Lysosomal-associated multispanning membrane protein-5 LAPTM5 Chr:1p34 AI589086 Hs.436200 -5.7 Below 2.8
92 205423_at adaptor-related protein complex 1, beta 1 subunit AP1B1 Chr:22q12 NM_001127 Hs.331602 5.6 Above 1.9
93 212929_s_at KIAA0592 protein KIAA0592 Chr:10q11.1 W68158 Hs.439367 5.6 Above 1.7
94 220606_s_at x 006 protein MDS006 Chr:17p13.1 NM_020233 Hs.47668 5.6 Above 2.0
95 212707_s_at polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa POLR2J Chr:7q11.2 AI738591 Hs.220255 5.6 Above 2.0
96 205101_at MHC class II transactivator MHC2TA Chr:16p13 NM_000246 Hs.126714 5.6 Above 2.5
97 218486_at TGFB inducible early growth response 2 TIEG2 Chr:2p25 AA149594 Hs.12229 5.6 Above 2.1
98 211323_s_at inositol 1,4,5-triphosphate receptor, type 1 ITPR1 Chr:3p26-p25 L38019 Hs.149900 5.6 Above 2.0
99 210377_at SA hypertension-associated homolog (rat) SAH Chr:16p13.11 D16350 Hs.512678 5.6 Above 2.2
100 336_at --- --- --- D38081 --- 5.6 Above 2.0