Reference Marker Normalization

• Mullighan et al (2007) normalized their SNP microarray data using a novel reference-marker normalization method.  The method is described briefly in the supplementary materials of the article. 
• We have developed a set of R routines to implement this procedure.  This User's Guide may be helpful in getting started.
• Here are the SNP annotation data, reference chromosome data, initial signal and call data, quantile-normalized signals, invariant-set normalized signals, directed reference-normalized signals, and automated reference-normalized signals. 
• To receive alerts regarding software updates, send an e-mail with "Updates on Reference Marker Normalization Software" in the subject line.
• More questions? Contact us.

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