Section
V
Evaluation of relapse
genes identified by Yagi et. al. on this
dataset
Recently Yagi et. al utilized the students
t-test to isolate a gene expression profile
which apparently correlated with prognosis
(no remission or relapse in less than 1 year
vs. complete response for more than 3 years). 13 When
an additional 36 cases were added, hierarchical
clustering separated the cases into good prognosis
and poor prognosis groups. Utilizing
HG-U95 to HG-U133 Best Match table available
on the Affymetrix website, HG-U133 probe sets
were identified for the 35 genes listed in
Table 2 of Yagi et.al.. When applied to the
98 cases of our dataset with adequate time
to follow-up, resulting clusters did not correlate
with prognosis and resulting Kaplan-Meier
curves were not different.
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