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Supplementary Information for: |
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Identification of genes associated with chemotherapy cross-resistance and treatment response in childhood acute lymphoblastic leukemia.
Sanne Lugthart 1,2,6,8 , Meyling H. Cheok 1,2,8 , Monique L. den Boer 6 , Wenjian Yang 1,2,5 , Amy Holleman 6 , Cheng Cheng 3 , Ching-Hon Pui 1,4,5 , Mary V. Relling 1,2,5 , Gritta E. Janka-Schaub 7 , Rob Pieters 6,9 , William E. Evans 1,2,5,9
1 Hematological Malignancy Program
2 Department of Pharmaceutical Sciences
3 Department of Biostatistics
4 Department of Hematology-Oncology ,St. Jude Children's Research Hospital , Memphis , USA
5 The Pharmacogenetics of Anticancer Agents Research Group in the Pharmacogenetics Research Network, Memphis , Tennessee , USA
6 Department of Pediatric Oncology/Hematology ,Erasmus University Medical Center/Sophia Children's Hospital, ,Rotterdam , The Netherlands
7 COALL study group ,Children's University Hospital , Hamburg , Germany
8 These first authors contributed equally to this work.
9 These last authors contributed equally to this work.
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Supplemental
Table 7: Overlap of
genes discriminating multiple-drug resistance and genes discriminating ALL subtypes
A. The overlap with the top
100 gene probe sets discriminating ALL genetic subtypes (TEL-AML1 [TEL],
hyperdiploid [HD], T-lineage [T]) (Ross et al., 2003; Yeoh et al., 2002) and
the 200 gene probe sets discriminating VCR-ASP
discordant resistance. Only 13 probe sets (11 genes) were in common.
B.
Furthermore, among the top 100 gene probe
sets discriminating ALL genetic subtypes (Ross et al., 2003; Yeoh et al., 2002) and the 51 gene probe sets discriminating cross-
resistance, there
were only three genes in common.
A
Probe
ID
|
ALL
Subtype
|
Title
|
Gene
Symbol
|
200709_at
|
TEL1
|
FK506
binding protein 1A, 12kDa
|
FKBP1A
|
202838_at
|
TEL1
|
fucosidase,
alpha-L- 1, tissue
|
FUCA1
|
203611_at
|
TEL1
|
telomeric
repeat binding factor 2
|
TERF2
|
203710_at
|
TEL1
|
inositol
1,4,5-triphosphate receptor, type 1
|
ITPR1
|
204849_at
|
TEL1
|
transcription
factor-like 5 (basic helix-loop-helix)
|
TCFL5
|
205267_at
|
TEL1
|
POU
domain, class 2, associating factor 1
|
POU2AF1
|
209695_at
|
TEL1
|
protein
tyrosine phosphatase type IVA, member 3
|
PTP4A3
|
221494_x_at
|
HD1
|
muscle
specific gene
|
M9
|
203680_at
|
HD2
|
protein
kinase, cAMP-dependent, regulatory, type II, beta
|
PRKAR2B
|
204849_at
|
TEL2
|
transcription
factor-like 5 (basic helix-loop-helix)
|
TCFL5
|
221748_s_at
|
TEL2
|
Homo
sapiens cDNA FLJ32766 fis, clone TESTI2001862
|
|
200709_at
|
TEL2
|
FK506
binding protein 1A, 12kDa
|
FKBP1A
|
221747_at
|
TEL2
|
Homo
sapiens cDNA FLJ32766 fis, clone TESTI2001862
|
|
B
Probe
ID
|
ALL
Subtype
|
Title
|
Gene
Symbol
|
200709_at
|
HD1
|
transcription factor 4
|
TCF4
|
202838_at
|
T2
|
CD79B
antigen (immunoglobulin-associated beta)
|
CD79B
|
203611_at
|
T2
|
immunoglobulin heavy constant mu
|
IGHM
|
1
Ross et al., 2003; 2 Yeoh et al., 2002 |
