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Supplementary Information for:

Identification of genes associated with chemotherapy cross-resistance and treatment response in childhood acute lymphoblastic leukemia.

Sanne Lugthart 1,2,6,8 , Meyling H. Cheok 1,2,8 , Monique L. den Boer 6 , Wenjian Yang 1,2,5 , Amy Holleman 6 , Cheng Cheng 3 , Ching-Hon Pui 1,4,5 , Mary V. Relling 1,2,5 , Gritta E. Janka-Schaub 7 , Rob Pieters 6,9 , William E. Evans 1,2,5,9

1 Hematological Malignancy Program
2 Department of Pharmaceutical Sciences
3 Department of Biostatistics
4 Department of Hematology-Oncology ,St. Jude Children's Research Hospital , Memphis , USA
5 The Pharmacogenetics of Anticancer Agents Research Group in the Pharmacogenetics Research Network, Memphis , Tennessee , USA
6 Department of Pediatric Oncology/Hematology ,Erasmus University Medical Center/Sophia Children's Hospital, ,Rotterdam , The Netherlands
7 COALL study group ,Children's University Hospital , Hamburg , Germany
8 These first authors contributed equally to this work.
9 These last authors contributed equally to this work.

Supplemental Table3 : Cross-validation using gene expression scores for cross-resistance and VCR-ASP discordant resistance.

Spearman's rank correlation (rho) and P-value for top probe sets discriminating cross-resistance and vincristine-asparaginase (VCR-ASP) discordant resistance are listed. In each iteration, based on 10-fold cross-validation, genes were reselected ( A ) or were not reselected ( B ).

	A				B
	Cross-resistance		VCR-ASP discordance		Cross-resistance		VCR-ASP discordance
Probe sets	rho	P-value	rho	P-value	rho	P-value	rho	P-value
30	0.50	<0.0001	0.45	<0.0001	0.74	<0.0001	0.63	<0.0001
51	0.52	<0.0001	0.45	<0.0001	0.73	<0.0001	0.63	<0.0001
100	0.53	<0.0001	0.46	<0.0001	0.72	<0.0001	0.62	<0.0001
200	0.50	<0.0001	0.53	<0.0001	0.70	<0.0001	0.64	<0.0001