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Supplementary Information for:

Identification of genes associated with chemotherapy cross-resistance and treatment response in childhood acute lymphoblastic leukemia.

Sanne Lugthart 1,2,6,8 , Meyling H. Cheok 1,2,8 , Monique L. den Boer 6 , Wenjian Yang 1,2,5 , Amy Holleman 6 , Cheng Cheng 3 , Ching-Hon Pui 1,4,5 , Mary V. Relling 1,2,5 , Gritta E. Janka-Schaub 7 , Rob Pieters 6,9 , William E. Evans 1,2,5,9

1 Hematological Malignancy Program
2 Department of Pharmaceutical Sciences
3 Department of Biostatistics
4 Department of Hematology-Oncology ,St. Jude Children's Research Hospital , Memphis , USA
5 The Pharmacogenetics of Anticancer Agents Research Group in the Pharmacogenetics Research Network, Memphis , Tennessee , USA
6 Department of Pediatric Oncology/Hematology ,Erasmus University Medical Center/Sophia Children's Hospital, ,Rotterdam , The Netherlands
7 COALL study group ,Children's University Hospital , Hamburg , Germany
8 These first authors contributed equally to this work.
9 These last authors contributed equally to this work.

Supplemental Figure 7: Hierarchical clustering using ALL subtype adjusted genes that discriminate VCR-ASP discordant resistance.

40 gene probe sets in rows with P<0.0008 discriminating VCR-sensitive plus ASP-resistant (blue, n=42) and VCR-resistant plus ASP-sensitive (orange, n=34) ALL cells in columns adjusted for TEL-AML1 and hyperdiploidy. Probe set ID, gene name and gene symbol (GS) are listed. The genes involved in protein biosynthesis (n=22) are highlighted with a magenta colored box. The heat map indicates high (red) or low (green) level of expression relative to scale shown. Notably, genes expressed at a low level commonly change by more than 2-fold whereas genes that are expressed at high levels typically change by less than 2-fold. ALL VCR-ASP discordant resistance genes related to protein synthesis are expressed at a relatively high level.