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Supplementary Information for:

Identification of genes associated with chemotherapy cross-resistance and treatment response in childhood acute lymphoblastic leukemia.

Sanne Lugthart 1,2,6,8 , Meyling H. Cheok 1,2,8 , Monique L. den Boer 6 , Wenjian Yang 1,2,5 , Amy Holleman 6 , Cheng Cheng 3 , Ching-Hon Pui 1,4,5 , Mary V. Relling 1,2,5 , Gritta E. Janka-Schaub 7 , Rob Pieters 6,9 , William E. Evans 1,2,5,9

1 Hematological Malignancy Program
2 Department of Pharmaceutical Sciences
3 Department of Biostatistics
4 Department of Hematology-Oncology ,St. Jude Children's Research Hospital , Memphis , USA
5 The Pharmacogenetics of Anticancer Agents Research Group in the Pharmacogenetics Research Network, Memphis , Tennessee , USA
6 Department of Pediatric Oncology/Hematology ,Erasmus University Medical Center/Sophia Children's Hospital, ,Rotterdam , The Netherlands
7 COALL study group ,Children's University Hospital , Hamburg , Germany
8 These first authors contributed equally to this work.
9 These last authors contributed equally to this work.

Supplemental Figure 6: Hierarchical clustering of ALL patients using genes discriminating cross-resistance and VCR-ASP discordant resistance.

A. Hierarchical clustering of cross-resistant (red dots, n=29) and cross-sensitive (blue dots, n=38) patients using genes discriminating cross-resistance. Listed for each patient are gender (sex), age and white blood cell count at diagnosis (WBC) and ALL subtype colored in green TEL-AML1-positive and in blue hyperdiploid (HD) ALL.

B. Hierarchical clustering of VCR-sensitive plus ASP-resistant (blue dots, n=42) patients and VCR-resistant plus ASP-sensitive (orange dots, n=34) patients using genes discriminating VCR-ASP discordance resistance.

C. Hierarchical clustering branch of patients using ALL subtype adjusted gene expression of VCR-ASP discriminating genes.