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Supplementary Information for:

Identification of genes associated with chemotherapy cross-resistance and treatment response in childhood acute lymphoblastic leukemia.

Sanne Lugthart 1,2,6,8 , Meyling H. Cheok 1,2,8 , Monique L. den Boer 6 , Wenjian Yang 1,2,5 , Amy Holleman 6 , Cheng Cheng 3 , Ching-Hon Pui 1,4,5 , Mary V. Relling 1,2,5 , Gritta E. Janka-Schaub 7 , Rob Pieters 6,9 , William E. Evans 1,2,5,9

1 Hematological Malignancy Program
2 Department of Pharmaceutical Sciences
3 Department of Biostatistics
4 Department of Hematology-Oncology ,St. Jude Children's Research Hospital , Memphis , USA
5 The Pharmacogenetics of Anticancer Agents Research Group in the Pharmacogenetics Research Network, Memphis , Tennessee , USA
6 Department of Pediatric Oncology/Hematology ,Erasmus University Medical Center/Sophia Children's Hospital, ,Rotterdam , The Netherlands
7 COALL study group ,Children's University Hospital , Hamburg , Germany
8 These first authors contributed equally to this work.
9 These last authors contributed equally to this work.

Supplemental Figure 5: Gene Ontology (GO) of genes discriminating cross-resistance and genes discriminating VCR-ASP discordant resistance.

Gene probe sets discriminating cross-resistance (CR) and VCR-ASP discordant resistance (VA) in B-lineage ALL patients were grouped according to 12 major functional categories. Each diagram shows the percentage of probe sets with GO annotation in the list of discriminating genes versus all genes represented on the U133A GeneChip. The entire genome, as represented by the 12,304 probe sets annotated in the GO database, has a total of 20,113 annotations. 51 probe sets discriminating CR (32 probe sets with GO annotation) and 200 probe sets discriminating VCR and ASP discordant resistance (142 probe sets with GO annotation) were used. Fisher's exact test (*P<0.05) was used to estimate significance of over- or under-representation of the discriminating probe sets.