|
Supplemental Table 8: Multivariate analysis of gene expression and known prognostic factors (age, WBC count) to discriminate in vitro drug resistance.
Multiple logistic regression was used with gene expression score (described in Supplemental Table 6), age and WBC count as continuous variables for the analysis in B-lineage ALL. An odds ratio >1 indicates increased probability of in vitro resistance.
| |
predictor |
odds ratio (95% C.I.) |
P-value |
PRED |
gene expression score |
57.8 (4.9-681.6) |
0.001 |
| |
age [years] |
1.17 (1.01-1.36) |
0.038 |
| |
WBC count [109/L] |
1.0 (0.98-1.01) |
0.427 |
VCR |
gene expression score |
13.5 (1.97-92.6) |
0.008 |
| |
age [years] |
1.0 (0.89-1.13) |
0.995 |
| |
WBC count [109/L] |
0.99 (0.99-1.0) |
0.084 |
ASP |
gene expression score |
22.1 (4.8-102.6) |
<0.001 |
| |
age [years] |
1.13 (1.01-1.26) |
0.033 |
| |
WBC count [109/L] |
1.0 (0.99-1.01) |
0.792 |
DNR |
gene expression score |
151.2 (4.1-5533.6) |
0.006 |
| |
age [years] |
1.04 (0.93-1.17) |
0.455 |
| |
WBC count [109/L] |
1.0 (0.99-1.0) |
0.273 |
|
