Supplemental Table 1: LC₅₀ values for classification of resistant and sensitive ALL for each chemotherapeutic agent.

LC₅₀ by MTT as described in Pieters and Kaspers et al^1,2. Classification based on LC₅₀-values previously associated with treatment outcome, as described in den Boer et al³.

Drug	Sensistive	Resistant
Prednisolone	≤ 0.100μg/ml	≥ 150μg/ml
Vincristine	≤ 0.391μg/ml	≥ 1.758μg/ml
Asparaginase	≤ 0.033IU/ml	≥ 0.912IU/ml
Daunorubicin	≤ 0.075μg/ml	≥ 0.114μg/ml