St. Jude Research/Supplemental Data/ALL2/pending

	Supplementary Information for:
	Gene-expression patterns in drug resistant acute lymphoblastic leukemia cells and response to treatment. Amy Holleman, Meyling H. Cheok, Monique L. den Boer, Wenjian Yang, Anjo J.P. Veerman, Karin M. Kazemier, Deqing Pei, Cheng Cheng, Ching-Hon Pui, Mary V. Relling, Gritta E. Janka-Schaub, Rob Pieters, and William E. Evans

Supplemental Figure 14 : Pathway analysis of genes associated with asparaginase resistance in B-lineage ALL.

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The 54 probe sets that were discriminative between asparaginase resistant and sensitive B-lineage ALL served as the input for the pathway analysis using Ingenuity software (http://www.ingenuity.com). The probe sets were mapped to the corresponding gene within the Ingenuity Pathway Knowledge Base. The pathway shown here is the biological network that included the highest number of genes queried. Highlighted genes are present in the set of 54 probe sets that were associated with asparaginase resistance in B-lineage ALL. The figure indicates the ratio of expression between resistant and sensitive cases (R/S ratio); green color represents underexpression and red color represents overexpression in asparaginase resistant ALL.